128 citations
,
August 2020 in “Cell stem cell” In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
90 citations
,
June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
43 citations
,
May 2011 in “Dermatologic Therapy” This article discusses the phases and histological features of alopecia areata and reports no new clinical findings; the authors emphasize recognizing these phases for accurate diagnosis.
42 citations
,
February 2018 in “International Journal of Molecular Sciences” This study suggests that minoxidil may enhance hair growth by stimulating adipose-derived stem cell motility and growth factor secretion, promoting dermal papilla cell proliferation and accelerating anagen induction.
31 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses the physiology of hair follicles, their disorders, and the principles behind developing treatments, reporting no new results.
25 citations
,
August 2006 in “Human Reproduction” This study found that the GGC repeat length significantly influenced testosterone levels in oral contraceptive users from high-risk breast cancer families, and homozygosity for short alleles may be linked to increased breast cancer risk.
17 citations
,
December 2014 in “Cell Stem Cell” This discussion explores advances in intravital imaging for visualizing stem cells, highlighting key discoveries and potential future developments; it reports no new experimental results.
10 citations
,
June 2016 in “Wound Repair and Regeneration” This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.
8 citations
,
January 1987 in “Gynecological Endocrinology” This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.
7 citations
,
January 2016 in “Methods in molecular biology” This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.
7 citations
,
November 2014 in “Histochemistry and Cell Biology” This study found that mutant mice with the we/we wal/wal genotype exhibit significant defects in hair shaft structure and epidermis stratification, correlating with postnatal alopecia symptoms.
2 citations
,
January 2019 in “Biomecánica” This review examines the roles of Hyaluronic Acid and Versican in the skin extracellular matrix and reports no new research findings, highlighting their involvement in processes like differentiation and wound healing.
1 citations
,
April 2019 in “Journal of Investigative Dermatology” This study found that cold atmospheric plasma can accelerate wound healing processes and reduce bacterial growth, including drug-resistant strains, suggesting its potential as a novel treatment for chronic wounds.
February 2026 in “Biochemical and Biophysical Research Communications” This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.
April 2025 in “Journal of Investigative Dermatology” This study found that fibronectin supports hair follicle regeneration by influencing stem cell behavior through integrin-dependent mechanotransduction, highlighting its potential role in epidermal renewal.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that miR-486 may protect against alopecia areata by maintaining hair follicle immune privilege and modulating expression of immune-related genes.
November 2013 in “Elsevier eBooks” This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.
April 2023 in “Journal of Investigative Dermatology” This study found that the dermal sheath smooth muscle regulates hair follicle progenitor cell death during hair regression through mechanical signaling of the TGF-β pathway.
April 2016 in “British Journal of Dermatology” Eyelashes are important for looks and eye protection, and more people are treating sparse eyelashes; more research is needed to understand eyelash biology and improve treatments.
112 citations
,
January 2004 in “The International journal of developmental biology” This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.
This study reviews the regulatory mechanisms and molecular processes governing stem cell activity in hair follicles, highlighting their roles in hair regeneration and potential implications for treating hair and skin disorders.
8 citations
,
May 2021 in “Bioengineering & translational medicine” This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.
75 citations
,
September 2017 in “Developmental biology” This review discusses circadian clock regulation in stem cells and its role in processes like neurogenesis, but reports no new results; the authors emphasize its significance in stem cell function across various tissues.
60 citations
,
June 1997 in “Journal of The American Academy of Dermatology” This review discusses the basic biology of apoptosis and its relevance to skin diseases, without presenting new research findings.
45 citations
,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that Myc superfamily transcription factors may have distinct roles in different epithelial compartments of the human hair follicle, possibly influencing cell fate in the putative stem cell compartment.
33 citations
,
November 2006 in “Survey of Ophthalmology” This report discusses the various causes and clinical assessment of madarosis, emphasizing the importance of recognizing and diagnosing associated vision or life-threatening conditions, without presenting new findings.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.
17 citations
,
December 2019 in “Stem Cells International” This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.
10 citations
,
January 2009 in “Elsevier eBooks” This review discusses the structure, functions, and growth cycle of human hair, emphasizing its reduced growth and protective roles, and reports no new research findings.
3 citations
,
December 2022 in “npj Regenerative Medicine” This review discusses the role of heparan sulfate proteoglycans in regulating stem cell fate and highlights their potential as targets for addressing hair loss, without reporting new clinical results.