October 2017 in “Universidad Nacional de Trujillo” This study found that low doses of hydroethanolic extract from Coffea arabica L. seeds reduced prostatic growth in mice with induced prostatic hyperplasia, while both low and high doses lowered uric acid and PSA levels.
September 2014 in “Hair transplant forum international” This issue contains notes by Dr. Bradley Wolf and mentions comments by Dr. Jerry Cooley, but it presents no new research findings.
This study determined that the optimal formulation for caffeine-based hydrogels involves 0.2% caffeine and 2.3% chitosan, based on gel liberation and stability testing.
This study developed nanoparticulate systems for caffeine delivery in hair follicles, demonstrating effective caffeine loading and release, as well as successful imaging within model hair follicles.
December 2022 in “Clinical and experimental dermatology and therapies” In this study, the addition of a topical gel containing growth-factor mimicking oligopeptides and other ingredients showed improved efficacy in subjects with androgenic alopecia using minoxidil or finasteride compared to drug treatment alone.
December 2022 in “Scientific Reports” This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.
This review discusses caffeine's potential role in treating androgenetic alopecia by counteracting DHT effects on hair follicles and enhancing cell proliferation, but reports no new clinical results.
This study conducted a pre-formulation evaluation of a caffeine shampoo for androgenic alopecia treatment, finding that the formulation remains stable under various conditions, suggesting its viability for compounding.
November 2013 in “Journal of Mazandaran University of Medical Sciences” This study found that a topical solution of caffeine and minoxidil 2.5% was more effective in treating androgenetic alopecia than minoxidil 2.5% alone.
5 citations
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October 2020 in “Giornale italiano di dermatologia e venereologia” This study found that a phyto-caffeine-containing shampoo was more effective than a control shampoo in reducing hair loss and improving hair strength in women with androgenetic alopecia over a 6-month period.
1 citations
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January 2019 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a gel containing extracts from Coffea arabica and Larrea divaricata was found to significantly thicken eyebrows and eyelashes in most premenopausal and postmenopausal women, without causing adverse effects, but showed no statistical difference from a placebo in overall hair growth.
January 2026 in “Reproductive Toxicology” In this study, daughters of mothers who consumed 8 or more cups of coffee per day during pregnancy experienced pubertal development about 2 months earlier than daughters of mothers who did not consume coffee, whereas no such differences were observed among sons.
July 2023 in “International journal of research publications” In this study, topical application of 45% robusta green coffee bean extract in male wistar rats did not significantly enhance hair growth but effectively inhibited the increase of 5α-reductase type 1 levels when exposed to testosterone.
55 citations
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March 2005 in “Neuropharmacology” A neurosteroid can reduce caffeine-induced anxiety in rats.
15 citations
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June 1996 in “Journal of Pharmacy and Pharmacology” This study suggests that measuring caffeine concentration in plasma and scalp hair can be a useful indicator of individual liver metabolic capacity among those consuming typical daily caffeine amounts.
42 citations
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June 2019 in “Aging” This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.
13 citations
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March 2020 in “Frontiers in cell and developmental biology” This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.
2 citations
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June 2022 in “Cells” The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.
December 2023 in “Asian journal of beauty & cosmetology” July 2022 in “Institutional Repositories DataBase (IRDB)” 3D spheroid cells effectively test hair growth compounds like Minoxidil.
November 2021 in “Research Square (Research Square)” This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.
January 2024 in “SSRN Electronic Journal”
March 2024 in “Daehan budongsan hakoeji/Daehan bu'dongsan haghoeji” Different factors like age, size, and location of subway stations affect sales of hair salons, coffee shops, and convenience stores in Seoul differently.
31 citations
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December 2023 in “GeroScience” 1 citations
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January 2025 in “Reproductive Biology and Endocrinology” This study suggests that supplementing with a cell-free fat extract might enhance embryo development and improve clinical outcomes in older women experiencing in vitro fertilization failure.
August 2023 in “Stem Cell Research & Therapy” This study found that cell-free fat extract (CEFFE) enhanced hair growth in mice with androgenetic alopecia by increasing hair follicle density and promoting proliferation while regulating the DHT/AR pathway.
94 citations
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May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” This study found that hair follicles contribute significantly to caffeine absorption shortly after topical application, with a faster absorption rate compared to the stratum corneum.
76 citations
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February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
67 citations
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November 2019 in “Molecules” This review collected findings on the various cosmetic and therapeutic properties of tea extracts, highlighting their antioxidant, anti-inflammatory, and photoprotective effects among other benefits for skin and hair care.
61 citations
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May 2014 in “International journal of pharmaceutics” This research describes a process for producing caffeine nanocrystals, which may enhance skin penetration by accumulating in hair follicles and maintaining stability for two months, paving the way for in vivo testing.