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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

GLI2 increases follistatin production in human skin cells.

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

CIP/KIP proteins help stop cell division and support hair growth.

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

Mice can regenerate ear tissue without the p53 protein.

UVB radiation changes the levels of certain microRNAs in skin cells, which may affect cell survival and hair growth.

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.