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    Glossary CDK inhibitors

    block enzymes that regulate cell cycle progression

    CDK inhibitors, or Cyclin-dependent kinase inhibitors, are a class of drugs that block the activity of enzymes known as cyclin-dependent kinases (CDKs). These enzymes play a crucial role in regulating the cell cycle, and their inhibition can halt the proliferation of cancer cells, making CDK inhibitors valuable in cancer treatment.

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    Research 30 of 267

    1. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors Science · 2001 · 153 citations
    2. Alopecia induced by CDK 4/6 Inhibitors and its Impact on the Quality of Life of Patients with advanced Breast cancer 2025
    3. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    4. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    5. Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7 Journal of Microbiology and Biotechnology · 2023 · 1 citations
    6. Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles Journal of Dermatological Science · 2001 · 9 citations
    7. Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis Expert Review of Anticancer Therapy · 2017 · 28 citations
    8. Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm Asia-Pacific Journal of Clinical Oncology · 2018 · 4 citations
    9. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change Journal of experimental botany · 2013 · 161 citations
    10. CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients. Journal of Clinical Oncology · 2019 · 4 citations
    11. Real-World Safety Profile of Generic Palbociclib in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer: A Prospective Observational Study in Iraq” Journal of cancer research updates · 2026
    12. Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Chemistry & biology · 2012 · 474 citations
    13. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    14. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    15. Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 Molecular cancer therapeutics · 2011 · 65 citations
    16. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    17. Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata Frontiers in Immunology · 2025 · 4 citations
    18. Cancer Treatments and Alopecia: A Systematic Review Turkiye Klinikleri Journal of Internal Medicine · 2021 · 2 citations
    19. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations
    20. Safety assessment of cyclin-dependent kinase 4/6 inhibitors and comparison of time to adverse events PLoS ONE · 2025 · 2 citations
    21. Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation Oncology Letters · 2017 · 2 citations
    22. Development of Stratum Corneum Lipid Liposomes for Topical Drug Delivery International Journal of Drug Delivery Technology · 2026
    23. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    24. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice American Journal of Pathology · 2014 · 8 citations
    25. HIF‐2α/ARNT complex regulates hair development <i>via</i> induction of p21 <sup>Waf1/Cip1</sup> and p27 <sup>Kip1</sup> The FASEB Journal · 2014 · 4 citations
    26. Abemaciclib-Associated Skin, Hair, and Nail Toxicities: A Case Report Curēus · 2024
    27. Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study Cancers · 2023 · 1 citations
    28. Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth Journal of Dermatological Science · 1995 · 20 citations
    29. The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? Dermatology Online Journal · 2009 · 39 citations
    30. Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis Pharmaceutics · 2022 · 1 citations