845 citations
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February 2001 in “The Journal of Clinical Endocrinology & Metabolism” This study identified the presence of the enzyme 1 alpha-hydroxylase in various extrarenal tissues, suggesting its potential role in modulating vitamin D function in peripheral tissues.
4 citations
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August 2017 in “Journal of cutaneous pathology” This case report documents only the second known instance of congenital lymphadenoma, expanding the diagnostic possibilities for cutaneous lymphoepithelial tumors in children.
1 citations
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October 2024 in “Indian Dermatology Online Journal” This case report describes a 36-year-old man who developed generalized eruptive histiocytosis on the scalp after undergoing nine platelet-rich plasma treatments for hair loss, likely triggered by injection-related trauma and inflammation.
This study investigated how different 3D bioprinted scaffold structures affect immune responses and hair growth in mice, finding that moderate immune response induced by certain structures stimulates hair growth, while excessive immune response can hinder hair follicle development.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, freezing gamma-irradiated amniotic fluid increased hair follicles and accelerated the transition to the anagen stage in rats, suggesting potential for treating hair loss safely and effectively.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Imaging Mass Cytometry effectively visualizes multiple biomarkers in alopecia areata, enhancing analysis of immune cell and tissue interactions in hair pathology.
November 2022 in “Journal of the Endocrine Society” This clinical case report identifies xanthomatous hypophysitis in a male patient, highlighting the mismatch between clinical symptoms and MRI findings, which led to a pituitary biopsy and accurate diagnosis instead of unnecessary surgery.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that infiltrating M2 macrophages promote wound-induced hair neogenesis in mice by producing growth factors that activate the wnt signaling pathway during the late phase of wound healing.
A 72-year-old man was diagnosed with a rare skin form of Rosai-Dorfman disease after years of misdiagnosis.
July 2026 in “Plastic & Reconstructive Surgery Global Open” This study found that intradermal injections of plant-derived exosomes in adults with early-stage alopecia increased stem cell activity, activated Wnt signaling pathways, and reduced certain immune cell populations, providing insights into their role in hair follicle regeneration and suggesting potential for hair restoration therapy.
July 2024 in “Journal of Investigative Dermatology” Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.
April 2023 in “Journal of Investigative Dermatology” This study suggests that linalool, a common allergen in personal care products, may contribute to frontal fibrosing alopecia pathogenesis by triggering immune responses and depleting hair follicle stem cells, especially in sensitized individuals.
November 2022 in “Journal of Investigative Dermatology” This study observed that dandruff is linked to a weakened immunoprivilege in hair follicles, with reduced Langerhans cells and increased epidermal CD4+ and CD8+ T cell infiltration.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.
July 2022 in “British Journal of Dermatology” This study found that epidermal growth factor receptor inhibitors used in cancer treatment induce a distinct inflammatory response in hair follicles, marked by immune privilege collapse and upregulation of inflammatory pathways.
April 2018 in “Journal of Investigative Dermatology” This study suggests that macrophages play a more substantial role in the pathogenesis of Lichen planopilaris compared to Frontal fibrosing alopecia, as indicated by increased CD68+ cells in Lichen planopilaris.
February 2023 in “Military Medical Science Letters” This study concluded that both pure-PRP and leukocyte-PRP injections significantly reduced serum CD 68 levels in knee osteoarthritis patients, with pure-PRP being more effective than leukocyte-PRP.
Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.
January 2025 in “Dermatology Research and Practice” In this research, RNA expression analysis of scalp biopsies from lichen planopilaris patients revealed changes in specific genes after treatments with hydroxychloroquine, narrow band UVB, or low level laser light therapy, suggesting potential biomarkers and implicating M2 macrophages in the disease's immunopathogenesis.
November 2020 in “Journal of The American Academy of Dermatology” This study examined dermoscopic features in African-American women with different types of alopecia and found that a perifollicular pink blush, potentially indicating inflammation, was common, particularly resolved with anti-inflammatory treatment, suggesting dermoscopy could aid in management.
9 citations
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October 2021 in “Biological and Pharmaceutical Bulletin” This study found that mupirocin nanoparticle-loaded hydrogel was safe and more effective for healing burn wounds in rats compared to mupirocin ointment, showing promise for future clinical trials.
4 citations
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December 2017 in “International Journal of Biomedicine” In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.
1 citations
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June 2024 in “PLoS ONE” This study found that implanting hair-follicle-associated pluripotent stem cell sheets facilitated wound healing and early macrophage activity while reducing inflammation in a diabetic mouse model, suggesting clinical potential for difficult-to-heal diabetic ulcers.
May 2022 in “Research Square (Research Square)” This study found that the newly developed transdermal oil body microgel emulsion (OBEME) improved wound healing in mice by enhancing skin permeability, reducing inflammation, and promoting new blood vessel formation and re-epithelialization.
February 2015 in “Journal of Biomedical Materials Research Part B: Applied Biomaterials” This study suggests that 4-META resin may be more effective than cyanoacrylate for promoting wound healing in rats, as the wounds were covered by epithelial tissue faster with 4-META resin.
June 2021 in “Journal of Cosmetic Dermatology” Laser treatment shows promise for hair growth, but needs further research.
773 citations
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August 2017 in “International Journal of Molecular Sciences” This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.
301 citations
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February 2019 in “Nature Communications” In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
271 citations
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May 2019 in “Cells” This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.
237 citations
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February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.