Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review explores the potential of periodontal ligament stem cells for regenerative therapy in periodontium, despite challenges due to their rarity, and reports no clinical results.

This review assessed the potential of mesenchymal stem cell therapy to enhance burn wound healing, highlighting its capabilities in promoting angiogenesis, reducing inflammation, and regenerating damaged tissues, while identifying preclinical and clinical challenges that need addressing to optimize treatment outcomes.

In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.

This study found that a combination therapy of oral corticosteroid and oral PUVA led to scalp hair regrowth in patients with intractable alopecia totalis and universalis within two months.

This study found that combining platelet-rich plasma with topical minoxidil led to the greatest increase in terminal hair density at 32 weeks, while low-dose oral minoxidil was more effective at reducing vellus hair density in men with androgenetic alopecia.

The study found that combining platelet-rich plasma with topical minoxidil significantly improved terminal hair density in androgenetic alopecia patients, while low-dose oral minoxidil was more effective at reducing vellus hair density.

In this study, hair follicle-derived mesenchymal stromal cells showed potential for immunomodulation, with equivalent or superior responses compared to those from adipose tissue, suggesting a promising alternative cell source.

This article discusses the role of regulatory T cells in alopecia areata, where their deficiency in hair follicles may lead to impaired local immunity and suggests potential therapies like CAR-T reg cells and low-dose IL-2 to alleviate autoimmunity and promote hair regeneration in affected individuals.

This source does not report original research findings but reviews the mechanisms and challenges of immune response and immunosuppressive management in liver transplantation.

This review highlights that Tremella fuciformis polysaccharide exhibits various bioactivities, such as antioxidant and immune-modulating effects, and explores its potential applications in food, pharmaceutical, and cosmetic industries.

This review discusses the role of extracellular vesicles in psoriasis pathogenesis and their potential as therapeutic agents or drug delivery systems, but it reports no new clinical findings.

This narrative review discusses the promising role of photobiomodulation in dermatology, emphasizing its non-invasive nature and potential benefits, but acknowledges the need for further research to establish standard protocols.

This study presents a new mouse model for investigating chronic graft-versus-host disease, highlighting the role of human thymic tissue in developing multiorgan fibrosis driven by human immune cells.

This review discusses the potential of combining low-dose IL-2 with islet antigens to enhance antigen-specific Treg function in type 1 diabetes, but reports no new clinical results.

This study developed immortalized human hair follicle-derived mesenchymal-like stromal cells (iHF-MSCs) as a consistent source of therapeutic secretome, reporting their superior immunomodulatory and regenerative performance, potentially advancing cell-free therapies for inflammation and tissue repair.

This study found that mouse skin CD4(+) memory T cells are in equilibrium with the circulation under steady state but increase in specific clusters in response to infection or inflammation.

CD44 variant changes start alopecia areata, but don't maintain it.

In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.

This study found that diphencyprone showed a significant clinical response for treating alopecia areata, while tacrolimus was not effective.

This study found that dermatological manifestations in HIV-positive individuals, such as infectious and non-infectious dermatoses, were significantly associated with CD4 T cell count.

This case report presents a young woman with systemic lupus erythematosus who was found to have CD4+ lymphocytopenia.

This study found that a high percentage of HIV-positive patients experienced mucocutaneous lesions, with conditions like oral candidiasis and furuncle being significantly associated with lower CD4 cell counts.

This study observed a wide range of mucocutaneous disorders among HIV-infected individuals in India, with a significant association between low CD4 cell counts and the presence of infectious and inflammatory skin conditions.

In this study, researchers found that CD4 is expressed on murine K5⁺ keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.

In this animal study, researchers discovered that CD4 T cells from mice with alopecia areata can induce the disease more efficiently than those from unaffected mice, likely by supporting CD8 T cell activation and hair follicle attack.

This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.

In this study, CD4+ non-haematopoietic, skin-resident stem cell-like populations were identified in both murine and human epidermis, suggesting they may serve as potential basal cell carcinoma precursors.

This study indicates that CD4 protein may have a functional role in basal cell-like keratinocytes through TCR/CD3-independent signaling, affecting their proliferation, differentiation, and migration.

This study found that patients with Alopecia areata in Iraq had significantly higher levels of CD4+, CD39+, and FOXP3+ Treg cells in their blood compared to healthy controls.

Certain immune cells in atopic dermatitis skin could be targeted for treatment.