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PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

Mice without collagen VI have slower hair growth normally but faster regrowth after injury.

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

Alkaline Ceramidase 1 prevents early hair loss in mice by keeping hair follicle stem cells balanced.

Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

Nestin identifies specific progenitor cells in hair follicles that can become outer root sheath cells.

Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.

Researchers found a good way to isolate hair follicle stem cells from newborn goats for further study.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

Lactate production is important for activating hair growth stem cells.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

CD4+ skin cells may be precursors to basal cell carcinoma.

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.