Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.

This study identified a reduced frequency of IL-10-producing regulatory B cells in alopecia areata patients, suggesting a protective role by these cells in disease development by regulating key immune mediators, such as IFN-γ and NKG2D+CD8+ T cells.

This study suggests that finasteride may upregulate BTG2 and CD244 gene expression through differential methylation, indicating potential as a treatment avenue for medulloblastoma.

This study found that PDGFA is critical for the proliferation and maintenance of adipocyte stem cells in skin but not other white adipose tissues, highlighting unique regulatory mechanisms in different tissue depots.

This study found that WNT10A is significantly upregulated in human esophageal squamous cell carcinoma and is associated with enhanced tumor cell migration, invasion, and poor survival.

This study found that RXR agonists stimulated human hair follicle growth and survival in vitro, suggesting potential for promoting hair growth in humans.

This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.

This study reported that in a mouse tail wound model, the synthetic dual inhibitor corin accelerated wound closure by enhancing re-epithelialization, and further in vitro experiments demonstrated increased expression of genes promoting keratinocyte migration, suggesting its potential as a treatment for chronic wounds.

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

This study found that patients with alopecia areata had significantly lower frequencies of IL-10 producing CD19+CD24hiCD38hi regulatory B cells compared to healthy volunteers, suggesting a potential role for these cells in the autoimmune response seen in the condition.

Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.

In this case report, a 24-year-old male with acquired distal trichorrhexis nodosa showed significant improvement after avoiding harmful hair treatments and using a repair shampoo alongside biotin and zinc supplements.

This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.

This review discusses the role of Lgr5 as a marker for identifying adult stem cells, particularly in the intestine and hair follicles, and reports no clinical results.

This study found that topical patidegib gel significantly shrank basal cell carcinomas in Gorlin syndrome patients without causing the systemic side effects common with oral hedgehog inhibitors.

This study investigates whether lymphocytes from mice with secondary alopecia areata can effectively induce the disease in a C3H/HeH mouse model, similar to lymphocytes from mice with spontaneous disease.

This study highlights a paradox where valproic acid, known for causing hair loss, may also promote hair growth when applied topically.

This review discusses the paradoxical effects of valproic acid on hair, noting that it can both cause alopecia and stimulate hair growth, but reports no new experimental findings.

This article discusses the paradoxical effects of valproic acid on hair, reporting both drug-induced hair loss and the potential for hair growth when used topically, but presents no original research findings.

Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.

This study observed that human primary adult hair matrix keratinocytes may have the potential to generate hair follicle organoids, suggesting possible applications in hair follicle neogenesis and preclinical hair growth agent screening.

This study found that platelet-derived growth factor secretion in PRP therapy for alopecia is highly variable between patients, which may contribute to inconsistent clinical responses.

Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.

This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.

This article reviews the biology of epithelial stem cells and their role in tissue self-renewal, maintenance, and regeneration, and it highlights the clinical implications of understanding their signaling pathways, but it presents no new clinical findings.

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

This study found multipotent progenitors in sweat ducts that become unipotent after sweat gland development, highlighting distinct regenerative capabilities in adult glandular skin stem cell populations.

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

Understanding where cancer cells come from helps create better prevention and treatment methods.