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This study found that patients with active severe alopecia areata exhibited decreased CD200 expression on T and B lymphocytes, which may be linked to an imbalance in Th1/Th2 immune equilibrium.

This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.

CD200 is not a reliable marker for identifying stem cells in all skin types.

This study reports that human hair follicle stem cells express different surface markers than mouse stem cells, facilitating their isolation and potentially aiding in the development of cell-based skin treatments.

This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.

This study found that selective downregulation of CD200 in the bulge area might contribute to unusual bulge involvement in a subset of alopecia areata cases.

This study found that thyroid hormones T3 and T4 enhance keratin 15 promoter activity and stimulate CD200 expression in epithelial stem cells from human scalp hair follicles, affecting their growth and differentiation.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

This review summarizes recent progress in human hair follicle bulge cell research, particularly the characterization and isolation of these stem cells, but reports no new experimental results.

In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.

This study reports that CD200R expression is significantly reduced in an experimental mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.

This study suggests that infiltrating M2 macrophages promote wound-induced hair neogenesis in mice by producing growth factors that activate the wnt signaling pathway during the late phase of wound healing.

This study investigated human hair follicle bulge cells and found that those with reduced CD200 expression exhibited enhanced hair regenerative capability, refining the functional understanding of bulge cell heterogeneity and providing insights for optimizing bulge cell–based hair regeneration techniques.

This study found that CD200-negative human hair follicle bulge cells have a higher hair-regenerative capability compared to CD200-positive cells, suggesting that reduced CD200 expression may enhance hair regeneration, providing insights for improving bulge cell-based hair restoration techniques.

In this study, rheumatoid arthritis patients showed no changes in the number of circulating follicular helper T cells, but these cells had increased CD200 expression, implicating them in disease pathogenesis and suggesting CD200/CD200R as a potential therapeutic target.

This study found that the CD301b-expressing subpopulation of macrophages plays a crucial role in promoting reparative processes during the mid-stage of skin wound healing in a mouse model.

In this study, a mouse model of scarring alopecia demonstrated significantly reduced CD200R expression in affected skin, which may contribute to immune attacks on hair follicles.

CD206+ macrophages are crucial for hair growth in alopecia areata treatment.

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

This article discusses the immune privilege in hair follicles and suggests that restoring its collapse might be an effective strategy for treating alopecia areata and cicatricial alopecia, but it reports no new clinical results.

This study reports that CD200R expression is significantly reduced in a mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.

This study found that canine bulge-derived keratinocytes are highly proliferative and can reconstitute pilosebaceous structures, indicating their potential utility in studying human stem cell biology and hair disorders.

This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.

Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.

This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

This paper presents a protocol for differentiating human-induced pluripotent stem cells into keratinocyte progenitor cells and keratinocytes, suggesting potential applications for hair follicle restoration and burn or ulcer therapy.

This study found that secondary wound healing in the anogenital/inguinal region after surgical intervention for hidradenitis suppurativa/acne inversa occurs significantly faster than in axillary wounds.

This study observed that skin stem cells in dogs could be identified using CD34 and CD200 markers, although further refinement in isolation and cultivation methods is needed for better identification.

This study observed that dandruff-affected scalp skin has increased T-cell infiltration in the epidermis and a reduction in the hair follicle's physiological immune privilege, particularly in the suprabulbar outer root sheath area, indicating a distinct immune microenvironment compared to healthy scalp.

This study reported that an ATRA-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) improved symptoms of alopecia areata in mice by enhancing transdermal drug delivery, reducing skin irritation, and promoting hair regrowth through targeted follicle enrichment and pathway activation.