April 2017 in “Journal of Investigative Dermatology” In this pilot study, researchers observed a correlation between clinical severity and histologic severity of lichen planopilaris, suggesting that an immunohistochemical scoring system could aid in grading disease activity.
212 citations
,
January 2017 in “Mediators of Inflammation” This review examines current treatments and the potential role of stem cells in cutaneous wound healing, but it presents no new clinical results and calls for more research on mechanisms.
52 citations
,
February 2012 in “PloS one” This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.
2 citations
,
April 2025 in “Journal of Investigative Dermatology” T cells affect skin cell genes in inflammatory diseases, and therapy can normalize these changes.
8 citations
,
February 2020 in “Fertility and Sterility” This study discusses treatment approaches for refractory Asherman syndrome, highlighting the potential role of CD133+ bone marrow-derived stem cells in conjunction with hysteroscopy for endometrial regeneration and improved pregnancy outcomes.
1 citations
,
September 2015 in “Elsevier eBooks” This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.
This study suggests that hair follicle dermal stem/progenitor cells play a key role in both hair regeneration and skin wound healing, with potential implications for preventing hair follicle miniaturization linked to aging or alopecia.
128 citations
,
August 2020 in “Cell stem cell” In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
41 citations
,
October 2019 in “Biomolecules” This review highlights the role of all-trans retinoic acid in regulating stem and progenitor cell proliferation and differentiation, suggesting its potential to enhance treatments in regenerative medicine and cancer.
January 2012 in “heiDOK (Heidelberg University)” In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.
411 citations
,
April 2010 in “Gastroenterology” This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.
3 citations
,
January 2014 in “Elsevier eBooks” Different stem cells have benefits and challenges for tissue repair, and more research is needed to find the best types for each use.
1 citations
,
April 2024 in “Cells” This review summarizes recent insights into corneal limbal stem cell differentiation and the potential role of progenitor-like cells, but reports no new experimental results.
January 2019 in “Advances in stem cells and their niches” This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
54 citations
,
August 2019 in “Bioscience trends” This review discusses the potential of stem cell secretome in regenerative medicine and suggests that its paracrine effects, rather than direct cell replacement, may drive therapeutic benefits.
October 2023 in “Biomaterials” This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.
131 citations
,
July 2009 in “Experimental Dermatology” This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.
January 2026 in “Asian Journal of Pharmaceutical and Clinical Research” This review discusses the potential of umbilical cord blood and umbilical cord-derived stem cells in treating various chronic diseases by highlighting their regenerative abilities and ethical advantages as well as the translational challenges and clinical implications.
4 citations
,
January 2021 in “Journal of Clinical Medical Research” This review provides an in-depth analysis of the structure and function of c-kit activation, and its role in both normal physiological and pathological conditions, with no new research findings reported.
1 citations
,
January 2018 in “Elsevier eBooks” This review examines the diversity and role of stem cells in the adult dermis, noting a lack of precise understanding about their hierarchy and relationship to dermal fibroblast subpopulations, and reports no new results.
55 citations
,
March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
30 citations
,
August 2021 in “Oncogene” This study reports that miR-22 promotes cancer progression and metastasis by maintaining Wnt/β-catenin signaling and cancer stem cell function.
26 citations
,
December 2016 in “Pharmacology & Therapeutics” This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.
136 citations
,
May 2019 in “Cells” This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
66 citations
,
March 2019 in “Cellular and Molecular Life Sciences” This review discusses melanocyte development, emphasizing the plasticity of melanoblasts and the role of both intrinsic and extracellular signals in their differentiation and migration, with no new clinical results reported.
62 citations
,
April 2009 in “British Journal of Dermatology” This review discusses the potential markers for identifying and studying stem cells in the epidermis and hair follicles, highlighting their role in understanding skin disease pathogenesis and expanding therapeutic options, but reports no new findings.
24 citations
,
November 2016 in “Cell death and disease” This review discusses the generation of germ cell-like cells from skin-derived stem cells and reports no new results; the potential for these cells to produce viable progeny remains unclear.
21 citations
,
January 2018 in “The Korean Journal of Physiology and Pharmacology” This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.
18 citations
,
April 2014 in “Stem cells” The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.
2 citations
,
June 2022 in “Scientific reports” In this study, one type of commercial culture medium supported expression of stem cell markers in hair follicle epithelial stem cells, but their differentiation potential and hair follicle-inducing ability declined over time.