61 citations
,
December 2021 in “Frontiers in Cell and Developmental Biology” This review discusses progress in targeted therapies for vitiligo, focusing on Janus kinase inhibitors and the potential of mesenchymal stem cells, but reports no new clinical results.
45 citations
,
June 2018 in “Frontiers in immunology” This study found that MDSC exosomes promoted partial hair regrowth and modulated immune responses in mice with alopecia areata, suggesting potential as a treatment for autoimmune diseases.
December 2021 in “Figshare” This review discusses recent advancements in targeted therapies for vitiligo, including JAK inhibitors and mesenchymal stem cells, and highlights the need for further research.
107 citations
,
October 2022 in “Frontiers in Immunology” This bibliometric analysis examines the research landscape of T cells in atherosclerosis and identifies key trends and emerging research areas, highlighting the field's stabilization over the past decade.
9 citations
,
March 2022 in “Frontiers in Immunology” This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.
286 citations
,
June 2012 in “Nature Immunology” In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.
91 citations
,
January 2010 in “Journal of Allergy and Clinical Immunology” This review explores the emerging roles of NK cells in various diseases, including allergies and skin conditions, and reports no new clinical results while indicating NK cell involvement in immune processes.
50 citations
,
April 2021 in “Frontiers in Immunology” This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.
41 citations
,
July 2019 in “Clinical Cosmetic and Investigational Dermatology” This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.
26 citations
,
June 2024 in “Frontiers in Immunology” The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.
26 citations
,
February 2021 in “FEBS Journal” This review discusses potential immune therapies targeting regulatory T cells for age-related diseases and emphasizes the need for further research to translate these therapies into clinical practice.
24 citations
,
May 2006 in “Journal of Investigative Dermatology” This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.
17 citations
,
May 2022 in “Frontiers in Immunology” This review explores recent advances in inflammation resolution and considers how macrophage reprogramming might help address severe COVID-19 outcomes, particularly those involving cytokine storms, but it reports no new experimental results.
9 citations
,
February 2022 in “BMC Genomics” This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.
7 citations
,
January 2025 in “Frontiers in Microbiology” In this study, researchers investigated the immunohistopathological characteristics of the skin in individuals during the acute phase of chikungunya infection, revealing CHIKV antigens and inflammatory infiltrates in various skin components and highlighting the role of cytokines/chemokines in the disease's skin manifestations.
7 citations
,
July 2013 in “InTech eBooks” This article describes the various presentations of oral lichen planus and notes it often requires topical or systemic immunosuppressive treatment for associated discomfort, but it reports no new clinical results.
3 citations
,
September 2025 in “Frontiers in Immunology” This review discusses the complex role of immune disturbances and the JAK-STAT pathway in alopecia areata, noting the success of JAK inhibitors in treatment, while highlighting ongoing debates and challenges in targeting other pathways like IL-17 and TNF-α.
3 citations
,
October 2023 in “Military Medical Research/Military medical research” This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.
1 citations
,
January 2025 in “Clinical Cosmetic and Investigational Dermatology” This study found that specific inflammatory factors, including decreased SCF, MIP-1β, and MCP-1, and increased SDF-1α and HGF, have causal relationships with rosacea, highlighting potential targets for further research into disease mechanisms.
1 citations
,
January 2023 in “International Journal of Molecular Sciences” This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.
July 2025 in “Cell & Bioscience” Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.
July 2025 in “Malaria Journal” This study suggests that while Nanostring profiling identifies important processes in resolving MA-ARDS, solely targeting late-stage resolution by altering SPM production is not enough. The researchers conclude that combining multi-targeted adjunctive therapies with antimalarial drugs may be necessary to enhance survival and recovery.
January 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This report discusses the Ninth World Congress for Hair Research and highlights the potential of hair follicle studies to advance understanding of various diseases, with no new clinical results presented.
1 citations
,
April 2017 in “Journal of Investigative Dermatology” This study suggests that alkaline phosphatase-regulated expression of CCL5 contributes to the trichogenicity of human dermal papilla spheres.
48 citations
,
September 2011 in “British Journal of Dermatology” This study found that DNA methylation and histone modification status were altered in peripheral blood mononuclear cells of patients with alopecia areata, suggesting these changes may contribute to the disease's pathological immune responses.
17 citations
,
October 2024 in “Journal of the American Academy of Dermatology” In this study, brepocitinib was found to significantly reduce inflammatory biomarker CCL5 expression and improve clinical severity by week 24, while maintaining a favorable safety profile.
2 citations
,
July 2024 in “Bioengineering” This study found that platelet-rich fibrin lysates modulate chemokine expression, reducing inflammation in oral squamous carcinoma cells, but increasing expression in primary oral epithelial cells.
June 2026 in “Health Science Reports” This study examined the genetic basis of alopecia areata by analyzing gene expression differences between patients and healthy controls, identifying critical pathways, hub genes, transcription factors, and miRNAs implicated in the disease, and suggesting potential targets for treatment.
September 2025 in “Figshare” This study conducted a scoping review and meta-analysis revealing a complex chemokine profile in alopecia areata patients, with elevated Th1, Th2, and other immune pathway chemokines, suggesting broader immunomodulatory strategies may help address the disease's multifaceted immune dysregulation.
September 2025 in “Figshare” In this scoping review and meta-analysis, researchers found that patients with alopecia areata show a complex serum chemokine profile, predominantly involving Th1- and Th2-associated chemokines, suggesting that broader immunomodulatory strategies might address the diverse immune dysregulation observed in the disease.