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This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.

This review discusses the role of oxidative stress in hair greying and suggests that understanding melanocyte susceptibility at different follicular locations may help develop therapies for preventing and reversing the process; it reports no new experimental results.

This article reviews the historical and scientific perspectives on the phenomenon of stress-induced changes in hair color and reports no evidence supporting the idea that holding or resigning from political office accelerates human aging or hair graying.

This study found that both acute and chronic exposure to nano polystyrene in laboratory rats disrupted hematological function, increased oxidative stress, and led to behavioral and physiological changes, like anemia-like effects and neurological disruptions, suggesting its potential as a cumulative toxicant.

This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.

This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.

This study reports that adjusting the valence states of Mo in Pluronic F127-coated MoO3-x nanozymes enhances their selective H2O2-related catalytic activity, showing promise in acute kidney injury treatment and enabling real-time monitoring of therapy effectiveness through ROS-responsive photoacoustic imaging.

This study found that targeting peroxisomal dysfunction with catalytic nanozymes enhanced hair follicle regeneration and outperformed minoxidil in promoting hair growth and maintaining efficacy in immunodeficient mice.

This study suggests that the susceptibility of hair follicle melanocytes to oxidative stress as they age may be key in the graying of hair due to reduced catalase expression and activity.

This study reports that keratinocytes grown under low oxygen conditions (physioxia) demonstrated reduced reactive oxygen species production and increased antioxidant enzyme activity compared to those in higher oxygen conditions, highlighting the role of oxygen in regulating skin antioxidant defenses.

This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.

This study found that patients with female pattern hair loss had higher oxidative stress levels and lower antioxidant enzyme activities than healthy controls, suggesting oxidative stress may play a key role in disease progression.

This study found that patients with alopecia areata had reduced erythrocyte SOD and GSH-Px activities and elevated plasma MDA levels, suggesting a potential role of oxidative stress in the disease's pathogenesis.

This study found that when human hair follicles are immersed in hydrogen peroxide, the resulting oxygen bubbles indicate catalase activity, and their absence may suggest tissue death.

In this study, azelaic acid was found to enhance UVB protection in bulge cells and, when combined with minoxidil, may promote hair growth through increased Sonic hedgehog protein expression in hair follicles.

This study found that an extract from the herbal medicine Ophioglossum vulgatum Linn. showed potential hair growth promotion and increased ATP and catalase activity in cell assays, suggesting its use in treating alopecia.

In this study, researchers introduced a machine learning approach to discover new nanozymes through the DiZyme platform, enabling the accurate prediction of multiple catalytic activities, and providing a comprehensive database and assistant resources for users.

In this study, fish-derived collagen hydrolysate from tilapia scales improved hair growth and skin health in both cellular and mouse models, reducing oxidative stress and inflammation while enhancing hair quality and promoting beneficial gene expression.

This review explores the role of oxidative stress and stem cell decline in hair graying, suggesting potential areas for future research but reports no new findings.

In this study, testing Annurca apple extract on human follicle dermal papilla cells indicated its potential to prevent patterned hair loss by reducing oxidative stress and increasing factors involved in hair growth.

In this study using animal models, microneedle patches loaded with artificial enzymes effectively treated androgenic alopecia, achieving results comparable to the over-the-counter drug minoxidil.

This study found that ursolic acid at 50 mg/kg improved biochemical, hormonal, and ovarian histopathological markers in a rat model of PCOS, suggesting its potential as a therapeutic option.

This study found that non-infectious skin conditions in sheep were associated with oxidative stress and changes in trace elements, vitamin A, and immunoglobulin levels.

Gray hair is caused by oxidative stress damaging hair cells.

This study found that hair follicle melanocytes show increased age-related susceptibility to oxidative stress compared to epidermal melanocytes, which may contribute to the graying of hair.

This study found that melatonin, when administered to Wistar rats prior to and after radiation exposure, reduced oxidative stress markers and histopathological damage in skin tissue compared to radiation alone, suggesting it may effectively prevent and treat radiation-induced skin injury.

This study describes a multifunctional hydrogel system designed to treat androgenetic alopecia by integrating nanozymes for reactive oxygen species clearance and melanin nano photothermal agents to enhance hair follicle health, suggesting potential for multi-target precision therapy and improved hair growth.

This study introduced an innovative nanozyme system called MCP@G, which was shown to improve diabetic wound healing in rats by alleviating mitochondrial oxidative stress, enhancing fibroblast migration, and promoting blood vessel and hair follicle regeneration, offering a promising approach for treating challenging diabetic wounds.

In this study, researchers examined 120 inbred maize lines infected with Fusarium graminearum, discovering that some demonstrated significant resistance to stalk rot, correlated with specific gene pathways. This highlights potential genes and pathways for enhancing disease resistance in maize.

This review discusses the promising roles of nanozymes in burn wound treatment, highlighting their broad enzyme-like activities that include antibacterial, anti-inflammatory, and pro-angiogenic effects, along with advantages over traditional treatments such as reduced drug resistance and higher stability.