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Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Androgens may block hair growth signals, targeting this could treat hair loss.

SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Some plant-derived compounds may help with hormonal conditions, but more research is needed to confirm their effectiveness.

Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.

Female hair loss linked to metabolic syndrome, not in males.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Spironolactone might help protect against severe lung problems in COVID-19 patients.

Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Gonadal hormones significantly affect the severity of alopecia areata in mice.