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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

Aldesleukin can treat certain cancers and increase HIV patient CD4+ counts but often causes severe side effects.

Perilla frutescens, an East Asian plant, contains 400 bioactive compounds that have various health benefits, including anti-inflammatory, antidepressant, and anticancer effects, and can treat conditions like diabetes, skin allergies, and neurological disorders.

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

New drugs for heart disease may be developed from molecules secreted by stem cells.

Isotretinoin can cause serious birth defects and needs careful use, especially in pregnant women.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Rosuvastatin improves lipid levels, reduces inflammation, but worsens insulin sensitivity in men with early-onset hair loss.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Vitamin D and its receptor are essential for hair growth, cell regulation, immune function, and heart health.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Doctors should check for serious tumor causes of high androgen levels in postmenopausal women and more research is needed on this condition.

Premature graying of hair may suggest health issues and currently lacks effective treatments.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

Oral minoxidil improves hair growth in men with hair loss, but caution needed for those with heart issues.

Hormone therapy may increase migraines in transgender women and decrease them in transgender men; more research is needed on migraine management in transgender individuals.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

Androgen use may increase the risk of stroke, but more research is needed.

Alopecia should be treated as a medical condition because it may increase the risk of serious diseases and psychological issues.

Not getting enough vitamin D can lead to health problems, so kids over one should get 600 IU/day.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.

DHEA supplementation may improve quality of life, neuropsychological functions, and sexual satisfaction in individuals with adrenal insufficiency, but more research is needed to confirm its safety and effectiveness.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.