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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

High androgen levels in young women with PCOS are linked to higher blood pressure.

Myrtle has various health benefits and potential for medicine development.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Premature graying of hair may suggest health issues and currently lacks effective treatments.

Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Obesity worsens Polycystic Ovary Syndrome symptoms, and weight loss is a key treatment.

New drugs for heart disease may be developed from molecules secreted by stem cells.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

Premature hair graying may be a sign of increased risk for heart disease, indicating biological age is more important than actual age.

COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.

The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.