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Diagnosing PCOS in teenagers should focus on signs of excess male hormones and not rely solely on ovarian ultrasound or irregular periods, and should be reassessed in adulthood.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

The regenerative solution, tSVF, is a safe and effective treatment for various conditions like aged skin, scars, wounds, and more, but more research is needed to find the best way to use it.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

Successful hair transplant surgery depends on careful patient selection, proper surgical plan and technique, and attentive aftercare.

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.

Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

Early-onset baldness is linked to a higher risk of aggressive prostate cancer in African-American men, especially before age 60.

The combination of cyclosporine and PUVA might help treat severe alopecia areata.

Mesenchymal stromal cells may help treat severe COVID-19, but more research is needed to confirm their effectiveness.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

New treatments for hair loss may target specific pathways and generate new hair follicles.

Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.

Most treatments for spondyloarthritis are safe, but monitoring and careful selection based on patient risks are important.

Lifestyle changes are the first step in treating infertility in PCOS, followed by medications like clomiphene and metformin, and then surgery if needed.

Unwanted facial hair significantly impacts over 40% of women's psychological and social well-being, and various treatment options are available.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Mild essential fatty acid deficiency can cause health issues and is worsened by low-fat diets.

Women experience various skin issues at different life stages, requiring careful treatment and awareness.

Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.