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Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

Men's age, urinary symptoms, and heart health risks create different types of erectile dysfunction.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

The document concludes that transsexual individuals often experience improved quality of life after transitioning, despite higher risks of psychiatric issues and mortality.

β-blockers can cause skin problems like psoriasis and vitiligo, and doctors should tell patients about these risks.

Intense exercise at night can delay the body's internal clock gene expression by 2 to 4 hours.

Medications for PCOS don't seem to raise heart disease risk.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Stress from being transgender is linked to higher blood pressure at night and more inflammation, which may affect heart health.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Genetic discoveries are key for understanding, diagnosing, and treating inherited hair and nail disorders.

Low testosterone in men is a risk factor for a specific heart rhythm issue, and testosterone treatment may help prevent it.

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Metformin and thiazolidinediones are similarly effective for PCOS, but metformin is often preferred due to fewer side effects.

iNOS contributes to hair loss in obese diabetic mice and blocking it may encourage hair growth.

Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Doctors should recognize and treat PCOS early in primary care to manage symptoms and lower risk of other health issues.

Children with classic congenital adrenal hyperplasia have thicker heart fat and more heart and blood vessel risk factors, especially if their condition is not well-controlled.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.