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Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Some medicinal plants can help heal wounds and may lead to new treatments.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Fat cells in the skin help start healing and form important repair cells after injury.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Skin fat helps with body temperature control and has other active roles in health.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Beta-caryophyllene helps improve wound healing in mice, especially in females.