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Hair straightening can damage hair and pose health risks, including exposure to carcinogens and hair loss.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.

Cancer development is like natural selection, involving mutated cells and environmental factors.

The transgene likely activated an oncogene or interrupted a tumor suppressor gene, causing melanoma in mice.

Heavy metals like arsenic, cadmium, and lead can increase cancer risk and worsen outcomes.

Vitamin D may help protect against nonmelanoma skin cancer.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Inactive hair follicle stem cells help prevent skin cancer.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Green-synthesized nanoparticles can effectively target cancer cells, reducing side effects and improving treatment.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

Certain hair straighteners and dyes may increase ovarian cancer risk, especially in African American/Black women.

Heavy metals in personal care products can cause serious health issues like cancer and hair loss.

The letter argues that blaming synthetic hair implants for scalp cancer based on one report is biased and possibly coincidental.

Onions may help reduce cancer risk and obesity-related issues.

Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.