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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Caffeine may benefit skin and hair health but more research is needed to confirm its effectiveness in dermatology.

Coloring shampoos for gray hair may cause gene mutation, reproductive issues, and skin damage, needing stricter regulation and expert consultation.

Oral contraceptives provide various health benefits beyond birth control, including managing menstrual issues, skin conditions, pain, and reducing the risk of certain cancers.

Phototherapy is effective and well-tolerated for treating childhood psoriasis and pityriasis lichenoides chronica.

Selenium is essential for health, but too much or too little can cause problems; blood selenium levels are a good measure of intake.

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

Filler injections can cause temporary hair loss, but hyaluronidase can help restore hair within a few months.

The first Japanese family with Marie Unna hereditary hypotrichosis showed hair condition improvement in a child and highlighted the risk of misdiagnosis.

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.

Some alternative therapies for vitiligo show promise but need more research.

Common cosmetic dermatology techniques improve skin damaged by the sun and aging.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

Herbal hair dyes from tannin-rich plants are effective and safer than synthetic dyes.

Lasers are less favored for hair transplant surgery but show promise for hair growth in controlled trials.

Maternal aspartame consumption during pregnancy leads to skin damage and higher apoptosis in newborn rat offspring.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Black ethnicity, prior PSA tests, enlarged prostate, and family history increase prostate cancer risk; Asian ethnicity, obesity, smoking, diabetes, and less sexual activity or no children decrease risk.