37 citations,
May 2011 in “Journal of Biological Chemistry” LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
17 citations,
December 2014 in “Cell Stem Cell” Intravital imaging helps us better understand stem cells in their natural environment and could improve knowledge of organ regeneration and cancer development.
3 citations,
May 2022 in “Oncogene” Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
1066 citations,
March 2010 in “Nature Reviews Molecular Cell Biology” MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.
144 citations,
March 2013 in “Circulation Research” K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.
124 citations,
December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
112 citations,
January 2014 in “Molecular and cellular therapies” Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.
91 citations,
March 2011 in “Stem Cells” Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.
77 citations,
January 2013 in “Journal of Investigative Dermatology” Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.
68 citations,
May 2018 in “PLOS Biology” Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.
60 citations,
July 2020 in “ACS Nano” Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.
59 citations,
September 2008 in “Experimental dermatology” Both mouse and rat models are effective for testing alopecia areata treatments.
46 citations,
June 2015 in “Journal of Investigative Dermatology” Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.
46 citations,
March 2015 in “Regeneration” Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.
45 citations,
July 2016 in “Journal of Dermatological Science” The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.
40 citations,
April 2014 in “Genes & Development” Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.
39 citations,
January 2013 in “Journal of Investigative Dermatology” Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
32 citations,
September 2016 in “Journal of Investigative Dermatology” STAT5 activation is crucial for starting the hair growth phase.
31 citations,
January 2014 in “Stem Cells” Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.
29 citations,
May 2010 in “Journal of Dermatological Science” Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.
28 citations,
February 2019 in “Genes” Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
23 citations,
February 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” NF-κB is crucial for different stages and types of hair growth in mice.
19 citations,
January 2018 in “BioMed Research International” miR-195-5p reduces hair growth ability in cells by blocking a specific growth signal.
18 citations,
October 2014 in “Experimental Biology and Medicine” Eating vitamin A affects hair growth and health by changing cell signals in mice.
15 citations,
September 2016 in “Biochemical Journal” Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.
13 citations,
January 2021 in “RSC chemical biology” Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.
13 citations,
November 2010 in “Experimental Dermatology” Vitamin C derivative reduces hair loss-related protein in cells.
13 citations,
February 2010 in “Stem Cell Reviews and Reports” Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.
11 citations,
February 2018 in “Amino acids” Copper and iron cause keratin damage in hair by converting methionine to homocysteine.
10 citations,
February 2017 in “Experimental Dermatology” Nail stem cells and Wnt signaling are important for fingertip regeneration but not sufficient for regenerating more complex limb structures.