127 citations
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August 2016 in “The oncologist” Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.
97 citations
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January 2020 in “Advances in chronic kidney disease” Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.
69 citations
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January 2015 in “Cell & tissue research/Cell and tissue research” Keratin mutations cause skin diseases and could lead to new treatments.
61 citations
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November 2011 in “Experimental dermatology” Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.
51 citations
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October 2000 in “Acta dermato-venereologica” PPAR alpha may help in hair growth and could be a target for treatment.
49 citations
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January 2022 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
31 citations
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November 2020 in “International journal of molecular sciences” Adipokines affect skin health and could be targeted for treating skin diseases.
29 citations
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June 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
24 citations
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March 2020 in “Cells” Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
18 citations
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October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
15 citations
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December 2021 in “Pharmaceutics” The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.
11 citations
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January 2021 in “General and comparative endocrinology” Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.
8 citations
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September 2021 in “Skin appendage disorders” Trichotillomania treatment is most successful with a mix of behavioral therapy, medication, and social support.
7 citations
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December 2017 in “Journal of dermatological science” Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.
6 citations
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May 2022 in “Biomedicine & pharmacotherapy” Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.
6 citations
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March 2022 in “Frontiers in drug discovery” Some small molecule antivirals show promise against COVID-19, but more research is needed to understand and improve them.
5 citations
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November 2021 in “Skin appendage disorders” Hair loss can cause stress and mental health issues, so treatments should address both the physical and psychological aspects, involving a team of dermatologists, psychologists, and hair specialists.
3 citations
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May 2022 in “Experimental Dermatology” Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.
2 citations
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July 2022 in “Frontiers in Medicine” The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.
2 citations
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July 2022 in “Frontiers in Cardiovascular Medicine” Forsythiasides have multiple health benefits but may cause pseudoallergic reactions, and more research is needed.
1 citations
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February 2024 in “Pharmaceutics” Nanovesicles improve drug delivery through the skin, offering better treatment outcomes and fewer side effects.
1 citations
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January 2024 in “International journal of molecular sciences” TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.
1 citations
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November 2023 in “Life” Hyaluronic acid injections can improve mouth opening and quality of life in scleroderma patients.
1 citations
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September 2023 in “Journal of Investigative Dermatology” Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.
1 citations
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October 2022 in “Annual review of cell and developmental biology” The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
1 citations
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January 2022 in “Stem cell biology and regenerative medicine” New methods to test hair growth treatments have been developed.
1 citations
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October 2013 in “PubMed” 1 citations
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November 2011 in “British journal of pharmacology” Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
May 2024 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying DMG-Na to the skin increases blood flow and may help with skin conditions.
April 2024 in “Molecules/Molecules online/Molecules annual” Paris polyphylla saponins may effectively treat acne due to their antibacterial and anti-inflammatory properties.