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    Glossary Cannabinoid Receptor Type 2

    protein involved in immune response and inflammation regulation

    Cannabinoid Receptor Type 2 (CB2 receptor) is a protein found primarily in the immune system and peripheral tissues. It plays a crucial role in modulating inflammation and immune responses. Unlike its counterpart, the CB1 receptor, which is mainly located in the brain and central nervous system, CB2 receptors are less associated with psychoactive effects and are being studied for their potential therapeutic benefits in conditions like chronic pain, autoimmune diseases, and even hair growth disorders.

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    1. 438 Laminin-511 is a new player in the development of psoriasis and controlled via cannabinoid receptor type 1 2016
    2. 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression 2018
    3. 1348 Involvement of mast cells and CB1 in the pathogenesis of IgA vasculitis Journal of Investigative Dermatology · 2023
    4. Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
    5. Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids FASEB bioAdvances · 2021 · 13 citations
    6. Cannabinoids and Their Receptors in Skin Diseases International journal of molecular sciences · 2023 · 1 citations
    7. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    8. Stem Cells and their Niches Journal of Investigative Dermatology · 2013 · 1 citations
    9. Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)" 2013
    10. A Summary of Pre-Clinical and Clinical Evidence for Cannabinoid Hair Follicle Effects Clinical dermatology open access journal · 2022
    11. Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases Cells · 2022 · 3 citations
    12. Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System Evidence-based Complementary and Alternative Medicine · 2020 · 2 citations
    13. Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System 2019 · 142 citations
    14. Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases? BioEssays · 2014 · 26 citations
    15. A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes<i>in vitro</i>and<i>in situ</i> PeerJ · 2013 · 66 citations
    16. Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal? EBioMedicine · 2017 · 28 citations
    17. Endocannabinoids limit excessive mast cell maturation and activation in human skin Journal of Allergy and Clinical Immunology · 2012 · 124 citations
    18. Frontal fibrosing alopecia: A review of disease pathogenesis Frontiers in Medicine · 2022 · 2 citations
    19. The impact of cannabis use on local anesthetic dosing during hair restoration surgery: a case report, proposed mechanisms, and clinical recommendations Journal of Dermatological Treatment · 2025
    20. 1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2) Journal of Investigative Dermatology · 2018
    21. Neuroendocrine Controls of Keratin Expression in Human Skin IntechOpen eBooks · 2018
    22. The aetiopathogenesis of acne vulgaris - what's new? International Journal of Cosmetic Science · 2014 · 14 citations
    23. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nature Clinical Practice Endocrinology & Metabolism · 2005 · 69 citations
    24. The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications Journal of Analytical Toxicology · 2011 · 22 citations
    25. Recent Progress in Prostaglandin F<sub>2</sub><i><sub>α</sub></i>Ethanolamide (Prostamide F<sub>2</sub><i><sub>α</sub></i>) Research and Therapeutics Pharmacological reviews · 2013 · 43 citations
    26. Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets Pharmaceutical Research · 2025 · 2 citations
    27. Beyond acne: Current aspects of sebaceous gland biology and function Reviews in Endocrine and Metabolic Disorders · 2016 · 97 citations
    28. Getting under the skin of hair aging: the impact of the hair follicle environment Experimental Dermatology · 2020 · 20 citations
    29. The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia Skin Pharmacology and Physiology · 2015 · 15 citations
    30. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations