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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.

Certain drugs that block specific enzymes can help treat prostate diseases.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Mutations in certain receptors can cause diseases and offer new treatment options.

Taking 5-Alpha Reductase Inhibitors before bladder removal surgery might make high-grade bladder tumors less aggressive.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

The project aimed to understand how genetic test results affect patients' actions and feelings in dermatology.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

A new compound, 3a, effectively fights prostate cancer better than finasteride.

The ITGB6 gene is important for tissue repair and hair growth, and mutations can lead to enamel defects and other health issues.

Adding a second method to PROTACs could improve cancer treatment.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Combining specific nanoparticles with immune therapy significantly improves cancer treatment.

The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

Eating apples can help prevent heart disease, cancer, and other conditions because they have healthy plant chemicals.

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.

The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

Exosomes are important for skin health and could help diagnose and treat skin diseases.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.