56 citations
,
February 2006 in “American journal of physiology. Cell physiology” This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.
56 citations
,
September 2016 in “Pharmaceutical Research” This study found that imiquimod combined with fish oil in a bigel formulation enhanced antitumor effects and reduced inflammatory side effects in a skin cancer model.
55 citations
,
November 2010 in “Journal of Allergy and Clinical Immunology” This study found that the TLR3 L412F genetic variant is associated with severe viral infections, especially CMV, and immune dysfunction in a subgroup of chronic mucocutaneous candidiasis patients.
52 citations
,
December 2020 in “Frontiers in Oncology” This review suggests that Chinese herbal medicine may help reduce side effects of chemotherapy in breast cancer patients, but a lack of high-quality trials limits confidence in this finding.
51 citations
,
September 2008 in “Journal of Investigative Dermatology” This article reviews the role of vitamin D receptor in protecting the skin from UV radiation-induced damage and tumor formation, but it reports no new clinical results.
50 citations
,
April 2010 in “Biology direct” This study's model suggests that low androgen levels can increase selection for prostate cancer phenotypes resistant to hormonal therapy, potentially leading to more aggressive forms of cancer.
49 citations
,
August 2009 in “British Journal of Cancer” This study observed that finasteride use among men with benign prostatic hyperplasia was associated with a decreased incidence of low-grade prostate cancer but not high-grade tumors.
44 citations
,
October 2010 in “BJUI” This study found that 5‐α‐reductase inhibitors reduce the risk of being diagnosed with prostate cancer in men who undergo regular screening, but increase the risk of sexual and erectile dysfunction.
43 citations
,
December 2020 in “PLOS Genetics” This study used a new statistical approach, PLACO, to identify several novel shared genetic regions associated with both Type 2 Diabetes and Prostate Cancer in two large GWAS datasets.
43 citations
,
October 2006 in “Journal of Cell Science” In this study, researchers found that contrary to expectations, keratin 10 domains did not reduce cell proliferation and instead increased tumor development in genetically modified mice.
42 citations
,
September 2018 in “Journal of Fungi” This study highlights the challenges in treating Microsporum canis infections due to variable antifungal drug efficacy and potential resistance, emphasizing the need for standardized methods to assess drug susceptibility.
38 citations
,
January 2020 in “Cell Transplantation” This study found that ACE2 and TMPRSS2 genes were more highly expressed in tumors of elderly male cancer patients compared to healthy individuals, with notable differences across age and gender.
38 citations
,
February 2011 in “Annals of Oncology” This study found that early-onset androgenic alopecia is associated with a higher risk of developing prostate cancer, although it was not linked to earlier diagnosis or more aggressive tumors.
35 citations
,
May 2008 in “Journal of Clinical Oncology” A cancer patient died from a severe skin reaction after taking the drug cetuximab.
35 citations
,
November 1996 in “Journal of the American Academy of Dermatology” This study reports two HIV-infected men with a rare M. canis infection unresponsive to ketoconazole and terbinafine, where itraconazole was effective but prolonged treatment led to only one cure.
34 citations
,
November 2023 in “Applied Materials Today” This review discusses the potential of topical nanoemulsions to transform skin cancer treatment by improving drug delivery and minimizing side effects, highlighting their advantages like enhanced skin permeation and controlled release, despite existing challenges.
34 citations
,
November 2013 in “Breast Cancer Research and Treatment” This study found that female breast cancer survivors using aromatase inhibitors were observed to have a higher likelihood of experiencing hair loss and thinning compared to those not treated with these drugs.
33 citations
,
January 2009 in “Journal of Cutaneous and Aesthetic Surgery” This study found no clear evidence that finasteride negatively affects erectile function, though it does cause a reduction in ejaculatory volume and has potential implications for prostate cancer risk.
32 citations
,
July 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” This review discusses the emerging roles of transit-amplifying cells in tissue regeneration and cancer formation, highlighting their significance beyond a mere transitional state in hair follicles and the hematopoietic system.
32 citations
,
September 2013 in “Breast cancer research” This study identified a specific SNP in the CACNB4 gene associated with a higher risk of chemotherapy-induced alopecia in breast cancer patients, which may help develop interventions to improve their quality of life.
30 citations
,
June 2010 in “Endocrine Related Cancer” In this study, dutasteride more effectively reduced prostate cancer cell viability than finasteride in vitro, but did not significantly alter the angiogenic response.
30 citations
,
January 2008 in “The Aging Male” This study found no difference in male pattern baldness between patients with benign prostate hyperplasia and prostate cancer, and no correlation with serum androgen levels.
28 citations
,
June 2010 in “European Journal of Cancer” This study found that androgenic alopecia at an early age was associated with a lower risk of prostate cancer, contrary to assumptions about androgens' role.
28 citations
,
January 2003 in “Urologic oncology” This review discusses the hormonal influences on prostate carcinogenesis and notes ongoing trials investigating whether finasteride could reduce prostate cancer incidence by inhibiting dihydrotestosterone synthesis, but it reports no new results.
28 citations
,
January 1999 in “Dermatology” This case report describes a dermatophytic granuloma caused by Microsporum canis in a heart-lung transplant recipient, emphasizing the need for systemic antifungal treatment in such deep infections.
27 citations
,
February 2014 in “BMC Cancer” The EPICAP study aims to investigate various factors influencing prostate cancer, including circadian disruption, inflammation, hormonal and metabolic factors, and genetic susceptibility, and reports no new clinical results.
27 citations
,
December 2014 in “Current problems in dermatology” This book reviews actinic keratosis from a multidisciplinary perspective, covering topics such as epidemiology, immunology, and clinical manifestations, but reports no new research results.
26 citations
,
September 1969 in “The American journal of medicine” This article reviews Cronkhite-Canada syndrome as a distinct condition from Peutz-Jeghers syndrome and familial polyposis, with cases showing gastrointestinal polyposis, skin, hair, nail abnormalities, and hypoproteinemia.
25 citations
,
June 2019 in “Endocrine Related Cancer” This review discusses the structure and function of steroid nuclear receptors, particularly focusing on androgen receptor dysregulation in prostate cancer and androgen insensitivity syndromes, without reporting new experimental results.
25 citations
,
April 2018 in “Electromagnetic biology and medicine” This study found that radiofrequency radiation from mobile phone use may increase DNA damage in hair follicle cells of the ear canal, with greater exposure duration linked to higher damage levels.