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The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

Keratins are important for skin cell health and their problems can cause diseases.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Finasteride improves hidradenitis suppurativa but not for child-bearing women.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Long-term finasteride use doesn't change bone density or metabolism.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.

Hair proteins have weak spots in their α-helical segments.

A gene in Arabidopsis thaliana, AtPRPL1, affects root hair length but not cell wall composition.

A new skin-whitening agent using a peptide from wheat is safe and effective at reducing skin pigmentation.

Two distinct pathways direct proteins to vacuoles in Arabidopsis, affecting root hair growth and protein targeting.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.