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The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Collagen XVII is important for skin aging and wound healing.

Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.

Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Lowering testosterone speeds up wound healing in male mice.

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

Finasteride improves hidradenitis suppurativa but not for child-bearing women.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.

Two distinct pathways direct proteins to vacuoles in Arabidopsis, affecting root hair growth and protein targeting.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

Minoxidil reduces lysine hydroxylase in skin cells.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Different combinations of human hair keratins affect how hair fibers form.

Allopregnanolone increases KCC2 expression in baby male rats' brains, while finasteride doesn't affect it.

Akt2 protein is essential for normal cell division in early mouse embryos.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.