Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that human C-tactile afferents respond to hair deflection, suggesting a functionally relevant anatomical relationship to hair follicles similar to that observed in mice.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.

This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.

This study estimates that approximately 230,000 tactile afferent fibers innervate the human body's skin, with varying densities across different regions correlating with spatial acuity and hair follicle density.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This study found that Florida manatees have unique types of specialized nerve endings in their vibrissae, which assist in their sensory and manipulative functions in aquatic environments.

In this study, researchers found that the glabrous skin of the rat forelimb contains sparse Meissner corpuscles and Merkel complexes, with more slowly adapting afferents in the palm and rapidly adapting afferents in the digit extremity.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study found no evidence supporting the hypothesis that Aβ afferents sprout into the superficial laminas of the spinal cord after nerve injury in rats.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This study found that in mice, competition for hair follicles guides the organization of follicle-innervating LTMR neurons during early development, with different neuronal subtypes showing varying adaptive responses to increased neuron populations.

Using synchrotron X-ray imaging, this study mapped the complex innervation of male rat vibrissa follicles, revealing distinct types of myelinated afferent neurons and patterns of axonal organization that may inform sensory processing in the brainstem.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.

This study found that distinct low-threshold mechanoreceptors innervate different hair follicle types in mice, suggesting that these follicles serve as unique mechanosensory structures in touch perception.

This study in male rats identified a unique type of mechanoreceptor, the club-like ending, which responds only to touch and not to self-motion during whisking, contrasting with other receptors that show mixed selectivity.

In this study, researchers used synchrotron X-ray imaging to examine rat vibrissa follicles, finding that despite variations in vibrissa length and follicle size, certain sensory structures remain consistent, suggesting specialized roles in sensory processing depending on the vibrissa type.

This article discusses scalp neuropathy in androgenetic alopecia and suggests that changes in tactile sensation due to Aβ fibers and increased nociception from circ-HTMR may be involved.

In this study, researchers identified two types of potassium channels, BK and Kv4.2, in rat Merkel cells and reported that these channels play important roles in repolarizing action potentials and maintaining resting membrane potentials, potentially influencing tactile encoding in these cells.

This study found that the vermilion border and mucosa of the monkey lip have a dense sensory innervation, which correlates with their known tactile sensitivity.

This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

This review discusses pharmacologic treatment options for muscle-related pain conditions and notes that there is strong evidence for the efficacy of tricyclic antidepressants and muscle relaxants in specific myofascial pain syndromes, but not universally.

This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

This article discusses objective methods for assessing hair loss and notes that most types of hair loss can regrow without treatment, but effective treatments for pattern or senescent alopecia remain unavailable.

This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.

This study found that inhibiting neurosteroidogenesis affected GABA A receptor-mediated synaptic inhibition in immature rats but not in adults, suggesting age-dependent modulation of synaptic strength in the spinal dorsal horn.

This review summarizes the anatomical and physiological aspects of human hair and its clinical significance, but does not report new research findings.

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.