84 citations
,
July 2003 in “European journal of biochemistry” This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.
24 citations
,
October 2022 in “Cell Regeneration” This study describes a new mouse model for vitiligo that mimics key clinical features such as skin depigmentation and CD8 + T cell infiltration, providing a useful tool for in-depth research and drug discovery.
10 citations
,
June 2009 in “Acta Biochimica Polonica” This study found that splenic melanosis in C57BL/6 mice is associated with synchronized skin melanization during hair cycles, but decreases with age.
6 citations
,
October 2018 in “PLoS ONE” This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.
13 citations
,
January 2022 in “Stem cell reviews and reports” This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.
June 2020 in “Comparative medicine” The study reported that Demodex musculi infestation was notably higher in immunodeficient mice, while infested immunocompetent mice, particularly the BALB/c strain, showed increased IgE levels and developed alopecia over time.
3 citations
,
May 2018 in “InTech eBooks” This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.
37 citations
,
February 2023 in “Gut Microbes” This study found that administering the gut bacterium Thauera sp. strain GDN1 to mice significantly reduced their serum androgen levels, indicating gut bacteria may influence androgen metabolism.
51 citations
,
January 2006 in “Wound Repair and Regeneration” This study found that MRL/MpJ mouse dorsal skin wounds heal with similar scar formation and collagen deposition as C57bl/6 and Balb/c mice.
1 citations
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March 2015 in “Journal of Visualized Experiments” This study developed a method to quantify hair loss in mice, aiding the evaluation of new treatments for alopecia.
6 citations
,
January 1998 in “Journal of Investigative Dermatology” This study found that oxybenzone is very stable under light exposure, contradicting previous findings of its oxidation to semiquinone after solar irradiation.
April 2023 in “Dermatology practical & conceptual” This study concluded that lenalidomide significantly induces the proliferation and migration of melanocyte stem cells, enhancing their differentiation into functional melanocytes in a mouse model.
32 citations
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December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that the effectiveness of 17-beta-estradiol in inhibiting hair growth depends on its application method, and noted significant sex differences in response to 17-alpha-estradiol in male and female mice.
March 2026 in “Trends in Sciences” This study developed a testosterone propionate-induced C57BL/6 mouse model of androgenetic alopecia, demonstrating that high-dose, prolonged testosterone administration inhibited hair regrowth and mirrored human AGA pathology, providing a useful platform for studying hair loss mechanisms and testing therapies targeting the Wnt/β-catenin pathway.
10 citations
,
December 2024 in “EXPERIMENTAL ANIMALS” This study found that aged C57BL/6 mice sub-strains exhibit distinct aging patterns, including differences in survival rates, body weight changes, and disease incidences, providing valuable insights for geriatric research using these mice models.
25 citations
,
November 2012 in “Phytotherapy Research” In this study, oral administration of Crataegus pinnatifida extract was associated with hair growth promotion in mice by inducing anagen phase and enhancing cell signaling related to hair follicle development.
4 citations
,
April 2011 in “International Journal of Radiation Biology” This study found that a newly developed mouse ear punch model effectively demonstrated that radiation significantly delays wound healing and may be used to study combined radiation and wound injury mechanisms.
3 citations
,
January 2016 in “Biotechnology and Bioprocess Engineering” This animal study found that Laminaria japonica mixed with insulin-like growth factor-1 significantly promoted hair growth in mice, suggesting its potential use for treating alopecia pending further clinical trials.
8 citations
,
January 1998 in “Journal of Investigative Dermatology” This study did not find any significant effects of estradiol or its antagonists on hair growth in two common mouse strains, challenging previous results reported by Oh and Smart.
56 citations
,
September 2010 in “Veterinary pathology” This study found that certain C57BL/6 mouse substrains have a genetic vulnerability to skin lesions resembling central centrifugal cicatrical alopecia in humans, potentially worsened by high vitamin A levels.
October 2025 in “Records of Natural Products” This research found that kaempferol, a flavonoid from hair growth-promoting plants, significantly enhanced human dermal papilla cell proliferation and inhibited specific signaling pathways, outperforming minoxidil, with topical application in mice promoting hair growth and thickness, indicating potential as a natural hair loss treatment.
June 2023 in “Current Issues in Molecular Biology” In this study, the alcoholic extract DN106212 from Centipeda minima was shown to be more effective in promoting hair growth in C57BL/6 mice compared to dimethyl sulfoxide and tofacitinib, suggesting its potential as a natural hair growth agent.
December 2013 in “대한피부미용학회지” In this study, wheat sprout extract (fr. 5) application was associated with increased hair growth in C57BL/6 mice, suggesting its potential as a hair remedy product.
1 citations
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January 2013 in “Asian Journal of Beauty and Cosmetology” This study found that wheat sprout extract promoted hair growth in female C57BL/6 mice, suggesting its potential application in hair remedy products.
11 citations
,
November 2009 in “Brazilian Journal of Medical and Biological Research” This study found that young C57BL/6 and BALB/c mice exhibit distinct regenerative patterns during ear wound healing, with greater wound closure but less regeneration in middle-aged C57BL/6 mice.
January 2018 in “Clinical dermatology open access journal” In this study, the researchers observed that Biofield Energy Treated herbal extracts enhanced hair growth and melanogenesis in C57BL/6 mice, suggesting its potential as a hair growth enhancer.
This study found that topical application of Sinsun-yukza-hwan extract significantly increased hair density and thickness in a mouse alopecia model and enhanced expression of growth-related genes.
42 citations
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March 2014 in “European Journal of Pharmacology” This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.
22 citations
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January 2014 in “Biological & Pharmaceutical Bulletin” This study found that ginsenoside F2 may suppress hair cell apoptosis and improve hair growth outcomes in a DHT-induced hair loss model more effectively than finasteride.
13 citations
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June 2020 in “Stem Cells International” In this study using a mouse model, ECM/SVF-CM, derived from adipose-derived stem cells, was observed to stimulate hair growth more effectively than SVF-CM by promoting cell proliferation, neovascularization, and anagen induction, which may support its potential as an improved treatment for hair loss.