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510-537 / 537 results![Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3](/images/research/9b49fb3d-b396-4872-ad86-c01a0b977e22/small/15097.jpg)
research Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3
The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
![Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1](/images/research/ff6e6cbe-cb9c-4d11-87ef-671d28ffd4fa/small/15506.jpg)
research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1
Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.
![Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione](/images/research/d83a3e64-f560-4ba4-a07b-c83a828239a2/small/25788.jpg)
research Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione
A new compound was made that might help treat diseases related to male hormones.
![New Progesterone Esters as 5α-Reductase Inhibitors](/images/research/7637f107-bfd4-4f11-881d-4e328591b835/small/15475.jpg)
research New Progesterone Esters as 5α-Reductase Inhibitors
Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
![Synthesis of 11α-Hydroxyprogesterone Haptens](/images/research/b8ac43f9-e150-4d84-a2a6-fdfeee5e833d/small/21148.jpg)
research Synthesis of 11α-Hydroxyprogesterone Haptens
Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
![VP-16-213 (Etoposide): The Mandrake Root from Issyk-Kul](/images/research/0b21e21a-ef33-43d3-ace6-6d9623c1bd37/small/22732.jpg)
research VP-16-213 (Etoposide): The Mandrake Root from Issyk-Kul
Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.
![Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism](/images/research/354fa00a-cb2d-4a3c-bf67-af83a6d02f0c/small/33123.jpg)
research Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism
Blocking CRF-R1 can reduce alcohol intake in stressed mice.
![Relative Binding Affinity of Novel Steroids to Androgen Receptors in Hamster Prostate](/images/research/9e236725-2b94-45ec-a3c3-37c7872e4193/small/15242.jpg)
research Relative Binding Affinity of Novel Steroids to Androgen Receptors in Hamster Prostate
New steroids were effective in blocking male hormone receptors in hamster prostates.
![Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs](/images/research/7fda0e28-5773-4e5b-b31b-8bdc6d217259/small/14420.jpg)
research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs
Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.
![DrugNet: Network-Based Drug–Disease Prioritization by Integrating Heterogeneous Data](/images/research/37e19cf1-0362-4f43-85e6-7ca53493c58b/small/14159.jpg)
research DrugNet: Network-Based Drug–Disease Prioritization by Integrating Heterogeneous Data
DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.
![Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys](/images/research/ea63462d-4b30-45f5-bb75-43dc3bd37636/small/1761.jpg)
research Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys
Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.
![Ganoderma Lucidum as an Inhibitor of Testosterone-Induced Prostatic Hyperplasia in Rats](/images/research/34894c52-08e6-4b0f-8674-0a41f9b8ac55/small/14747.jpg)
research Ganoderma Lucidum as an Inhibitor of Testosterone-Induced Prostatic Hyperplasia in Rats
Ganoderma lucidum may help treat enlarged prostate in rats.
![In Vitro and In Vivo Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring](/images/research/9532cf10-fa54-42be-917b-f5c0471557b0/small/15267.jpg)
research In Vitro and In Vivo Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring
Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.
![Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases](/images/research/b462824e-f94c-459b-809e-72dbf27e203e/small/13950.jpg)
research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
![Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase](/images/research/d19df8a7-8de6-4430-8a0d-4ffa1f502985/small/15608.jpg)
research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase
New compounds were made that effectively block a specific enzyme related to androgen conditions.
![A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer](/images/research/593040da-4098-449c-92f2-887cd7dcb43a/small/15031.jpg)
research A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.
![Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol](/images/research/36573896-2135-4d38-aab0-e0ce67343940/small/14022.jpg)
research Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol
Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.
![Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice](/images/research/f66aa477-6993-472c-a555-4feb295267ee/small/2743.jpg)
research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice
Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.
![Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride](/images/research/fa3cdf0c-c7b7-4025-9d4e-121a4258f109/small/4968.jpg)
research Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride
Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
![Anti-Müllerian Hormone Confirms the Novel Classification of Female Functional Androgenization Including Polycystic Ovary Syndrome](/images/research/3ea4e126-d6d9-4ac0-9c09-a14467bc84bb/small/26141.jpg)
research Anti-Müllerian Hormone Confirms the Novel Classification of Female Functional Androgenization Including Polycystic Ovary Syndrome
Anti-Müllerian hormone is a specific marker for ovarian issues in women with conditions like PCOS.
![Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs](/images/research/ea91e119-6921-410b-b097-7565a6693198/small/17289.jpg)
research Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs
Nanoporous silica entrapped lipid-drug complexes significantly improve the solubility and absorption of drugs that don't dissolve well in water.
![Possible Contributory and Protective Factors in Medication Associated Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System](/images/research/991dfee1-a0cf-4c23-aeae-28d9a354fd9b/small/12097.jpg)
research Possible Contributory and Protective Factors in Medication Associated Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System
Some drugs may increase the risk of obstructive sleep apnea, while others like certain biologics might decrease it.
research Design, Synthesis, and Biological Evaluation of Novel Androst-3,5-Diene-3-Carboxylic Acid Derivatives as Inhibitors of 5α-Reductase Type 1 and 2
New chemical compounds were made that effectively block an enzyme linked to prostate growth.
![Androgens and Ovarian Function: Translation from Basic Discovery Research to Clinical Impact](/images/research/58ba045c-e1a3-4169-8b75-9748beb8a43d/small/13353.jpg)
research Androgens and Ovarian Function: Translation from Basic Discovery Research to Clinical Impact
Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.
![Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System](/images/research/044abf40-8278-46c6-86d8-34c61d13ce0c/small/17062.jpg)
research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System
Testosterone and its metabolites affect brain functions and could help treat neurological disorders.
![Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade](/images/research/41b4cfdf-1dd4-41a6-9945-4e9eefa64a63/small/20763.jpg)
research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade
Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.