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Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Transplant success has improved with better immunosuppressive drugs and donor matching.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Smart biomaterials that guide tissue repair are key for future medical treatments.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

The 308-nm excimer laser is a promising treatment for vitiligo with varying success and mild side effects.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

New drug delivery methods can make natural compounds more effective and stable.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.

COVID-19 can cause skin issues like chilblains and rashes, which may help in early detection, especially in patients without other symptoms.

The European Society of Cutaneous Lupus Erythematosus created a questionnaire to standardize patient assessment and improve care for cutaneous lupus.

Hyaluronic acid-based HA2 hydrogel helps heal skin wounds better with less scarring.

Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Taking L-tryptophan supplements might cause a condition similar to scleroderma in some people, which can get better after stopping the supplement and starting corticosteroid therapy.

The document concludes that PK/PD modeling is important for determining the safe and effective dosages of drugs.