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30-60 / 1000+ resultsresearch Characterization of dermal type I collagen of C3H mouse at different stages of the hair cycle
This study found that collagen remodeling is more active in anagen-stage skin than in telogen-stage skin in mice, suggesting that collagen modifications may support hair follicle growth and migration.
research Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice
The laser comb did not improve hair regrowth in mice with alopecia areata.
research Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata
This study found that gonadal steroid hormones influence alopecia areata in C3H/HeJ mice, with estradiol promoting progression and dihydrotestosterone conferring resistance to disease onset.
research Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice
This study found that 2% ketoconazole solution stimulated hair growth significantly in a mouse model, suggesting potential benefits for male pattern hair loss.
research The antiinflammatory effects of Xuefu Zhuyu decoction on C3H/HeJ mice with alopecia areata
research Promoting Effect of Herbal Extracts Mixtures on Hair Regrowth in C3H/HeJ Mice
In a mouse study, topical application of certain herbal extract mixtures showed accelerated hair regrowth compared to controls, with noted increases in specific enzyme activities and growth factors that may aid alopecia treatment.
research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice
This study found that dermal injection of M-CSF stimulated CD11b + myeloid cells can induce alopecia areata in mice by potentially activating B lymphocytes, offering insight into the disease's pathogenesis.
research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata
CD44 variant changes start alopecia areata, but don't maintain it.
research Dietary soy oil content and soy‐derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice
This study found that increasing dietary soy oil content reduced alopecia areata development in C3H/HeJ mice, though genistein injection showed no significant effect.
research Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice
This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.
research Low-level laser treatment stimulates hair growth via upregulating Wnt10b and β-catenin expression in C3H/HeJ mice
This study found that low-level laser treatment may promote hair regrowth in mice by activating the Wnt10b/ß-catenin pathway and inducing the anagen phase of hair follicles.
research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata
This study found that total glucosides of paeony (TGP) reduced hair loss and inflammation in alopecia areata mice by inhibiting cellular pyroptosis.
research Effects of Gymnema sylvestre Leaf Extract Formulation on Hair Growth Inhibition in C3H mice
In this study, a 5% Gymnema sylvestre leaf extract formulation applied to C3H mice showed significantly delayed hair regrowth by increasing TGF-β1 and TGF-β2 expression while reducing β-catenin levels, suggesting its potential as a natural hair growth inhibitor.
research 699 Pharmacological blockade of the CX3CR1/CX3CL1 fractalkine axis prevents alopecia areata in C3H/HeJ mice
research The Functional Relevance of the Type 1 Cytokines IFN-γ and IL-2 in Alopecia Areata of C3H/HeJ Mice
This study found that IFN-γ plays a critical role in T cell activation and the pathogenesis of alopecia areata in C3H/HeJ mice.
research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice
This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.
research 042 Characterization of Pathogenic CD8+ T Cells in an adoptive transfer Mouse Model of Alopecia Areata in C3H/HeJ mice
Certain CD8+ T cells attack hair follicles in alopecia areata, suggesting they could be targeted for treatment.
research 006 Exogenous IL-27 promotes immunosuppressive T cells and prevents the development of alopecia areata in C3H/HeJ mice
IL-27 may help prevent hair loss in alopecia areata by promoting immunosuppressive T cells.
research 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata
In this study, a single subcutaneous dose of PTH-CBD showed similar hair regrowth to daily oral ruxolitinib in mice with alopecia, possibly through increased beta-catenin and anagen transition stimulation.
research Alopecia areata
This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.
research Alopecia Areata: A tissue specific autoimmune disease of the hair follicle
This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.
research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib
This study observed that baricitinib treatment led to significant improvement in a patient's alopecia areata symptoms and suggests further clinical trials to explore its potential as a treatment.
research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans
Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells
This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.
research Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies
This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.
research Comparison of Alopecia areata in Human and Nonhuman Mammalian Species
This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.
research Alopecia areata − animal models
This review discusses rodent models of alopecia areata and highlights genetic and epigenetic factors influencing its development, but reports no new experimental results.
research Regulation Mechanisms of Hair Growth
This study observed that repeated shaving and topical treatments, particularly TPA, stimulated hair regrowth in C3H mice, while certain treatments like betamethasone valerate completely inhibited it.
research Alopecia Areata
This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.