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This study found that an enzymatic digestion method for isolating hair follicle stem cells from scalp specimens yielded 5.3 times more epithelial cells than explant cultures, while supporting comparable cell functionality, offering a promising technique for tissue engineering and regenerative medicine.

This study found that apple stem cell extract may selectively influence hair follicle bulge stem cell biology without cytotoxic effects in an ex vivo human hair follicle organ culture.

This study found that epithelial stem cells from plucked hair follicles grow optimally when cultured on 3T3 fibroblasts feeders.

This study established a new cell line from human hair follicle stem cells that maintains stem cell properties and differentiation capabilities, providing a useful in vitro model for stem cell research.

This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.

This study reports the creation of a human dermal mesenchymal-like stem cell line from an androgenetic alopecia patient, which may serve as an in vitro model to explore alopecia mechanisms.

This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

This study found that stem cells from mouse hair follicles successfully reconstructed the ocular surface in most limbal stem cell deficiency mice, demonstrating potential for treating the condition in a mouse model.

This study found that human embryonic and induced pluripotent stem cells differentiated into specific bulge stem cells and successfully formed new hair follicles when transplanted with mouse dermal cells in immunodeficient mice.

This study suggests that damaged anagen hair follicles have the capability to repair themselves and resume growth by mobilizing extra-bulge epithelial cells, particularly after injuries like chemotherapy and radiotherapy.

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.

In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.

This study demonstrated that adding human adipose-derived stem cells to hair follicle germ-like aggregates significantly improved hair shaft generation in transplanted nude mice, suggesting a promising strategy for hair regenerative medicine.

This study reported the successful isolation of epithelial stem cells from mouse embryonic skin using a simple culture method, with the cells showing the potential to differentiate into multiple cell types.

This study identified a specific subpopulation of hair follicle stem cells in mice and humans that are essential for long-term hair regeneration, highlighting the potential for regenerative therapy.

This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.

In this study, one type of commercial culture medium supported expression of stem cell markers in hair follicle epithelial stem cells, but their differentiation potential and hair follicle-inducing ability declined over time.

This study found that RANK-RANKL signaling regulates hair renewal and epidermal homeostasis in mice, revealing its role in initiating hair growth cycles and maintaining skin cell activity.

This study revealed that during fetal development, MITF and Mart-1 expressing melanocytes progress from the dermis to the epidermis and hair follicles, with MITF possibly marking follicular stem cells.

In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.

The K15 promoter effectively targets stem cells in the hair follicle bulge.

In this study, Wnt-3a was found to play an important role in partially maintaining and expanding epithelial skin stem cells in vitro, suggesting potential for in vitro stem cell culture without feeder cells.

This study found that combining a human acellular amniotic membrane with iPSC-derived epithelial stem cells effectively repaired skin defects and promoted hair follicle formation in nude mice.

This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.

This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.

This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.

This study found that human induced pluripotent stem cells differentiated precisely to express certain markers during a specific window could enable successful hair follicle generation when transplanted.