Search
for
Sort by
Research
90-120 / 1000+ results
research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway
This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.
research Polymorphism
This chapter discusses phase transitions in various pharmaceutical examples and does not present any new research findings.
research Clobetasol/minoxidil
research Structural characterization and dissolution profile of mycophenolic acid cocrystals
This study found that the cocrystal of mycophenolic acid with isonicotinamide significantly improved solubility and dissolution rate, while two other cocrystals showed decreased performance in these areas.
research Unsaturated Halogenated Hydrocarbons
This review discusses the uses and toxicological data of eleven unsaturated halogenated hydrocarbons, including dichloroacetylene, allyl chloride, hexachlorobutadiene, β-chloroprene, vinyl chloride, trichloroethylene, and perchloroethylene, but presents no new findings.
research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1
This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.
research Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate
In this study, researchers found that both thermolabile and thermostable forms of phenol sulfotransferase contribute to the sulfation of minoxidil, emphasizing the need to consider both enzymes in assessing sulfation in human tissues.
research Unsaturated Halogenated Hydrocarbons
This article reviews the properties, uses, and toxic effects of eleven unsaturated halogenated hydrocarbons, highlighting the risks associated with compounds like dichloroacetylene, allyl chloride, and vinyl chloride, and reports no new experimental findings.
research Attenzione divisa nei pazienti con cerebrolesione acquisita
This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.
research Determination of Phenolic Compounds Composition of Water Extracts of Equisetum arvense (L.)
This study found that Equisetum arvense, or horsetail, water extracts prepared with polyethylene glycol in an ultrasonic bath yielded the highest levels of phenolic compounds, such as hydroxycinnamic acids and flavonoids, indicating that this method improves the release of biologically active substances.
research The potential use of phenolic compounds in the treatment of hair loss: a literature review
This study reviewed in vivo studies and clinical trials on phenolic compounds, like tannins and flavonoids, for treating hair loss, noting their antioxidant and anti-inflammatory effects but highlighting the need for more clinical trials to confirm benefits.
research Impaired Cardiometabolic Effects of Bromocriptine in Men With Early‐Onset Androgenic Alopecia
This study found that men with early-onset androgenic alopecia are less responsive to the cardiometabolic effects of bromocriptine compared to men with normal hair growth.
research A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea
This article compares cabergoline and bromocriptine for treating hyperprolactinemic amenorrhea and reports no specific findings.
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
This research article focuses on nonsteroidal inhibitors of human type I steroid 5-alpha-reductase but reports no new results.
research Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Nontested Compounds
This study found that certain molecular quantum descriptors can be directly correlated with the biological activity of benzo[c]quinolizin-3-ones, potentially aiding in the identification and design of active compounds.
research Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model
This study found that Croton membranaceus root extract induced CYP1A2 and GSTM1 enzymes but inhibited CYP3A4 and CYP2D6 in rat livers, suggesting caution in its use with other drugs.
research Optimization of polyphenol extraction from Eclipta prostrata L. by response surface methodology
In this study, researchers optimized the extraction conditions for polyphenols from the medicinal herb Eclipta prostrata, achieving the highest polyphenol content under specific conditions of temperature, solvent concentration, and time, and found the extract to have significant antioxidant activity.
research SUBSTYTUCJA EGZOGENNYCH CHOLINESTERAZ W LECZENIU CIĘŻKICH ZATRUĆ ZWIĄZKAMI FOSFOROORGANICZNYMI
This study reports a successful combination treatment for phospho-organic compound poisoning, using standard therapy with atropine and toxogonin along with exogenous cholinesterases via blood transfusion, showing positive outcomes in patients whose endogenous cholinesterase levels dropped to 20%.
research Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model
This study found that exposure to hair bleach aerosols containing persulphates and hydrogen peroxide induced airway hyperresponsiveness to acetylcholine in rabbits.
research Alternative synthesis of the anti-baldness compound RU58841
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
research Sulfation of minoxidil by human liver phenol sulfotransferase
This study found that minoxidil is bioactivated through sulfation by the phenol-sulfating form of phenol sulfotransferase in human liver.
research Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle
This study found that cromakalim and pinacidil significantly inhibited porcine detrusor muscle contractions, suggesting these ATP-sensitive potassium channel openers may have potential in treating certain bladder diseases.
research Determination of Residual Organic Solvents in Finasteride Raw Materials by Headspace Capillary Gas Chromatography
This study established a sensitive and reproducible method for determining the levels of four organic solvents in finasteride raw materials, meeting the requirements of the Chinese Pharmacopeia.
research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2
This study identified potent dual inhibitors of 5α-reductases 1 and 2 that may aid in designing new drugs for related diseases.
research Phenomenology of polymorphism: The topological pressure–temperature phase relationships of the dimorphism of finasteride
In this study, researchers found that finasteride exhibits a solid-solid phase relationship that is enantiotropic at normal pressure and becomes monotropic at higher pressure.
research Aqueous Extract of Bacopa procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson’s Disease Model
This study found that an aqueous extract of Bacopa procumbens improved motor function and preserved neuronal structure in a mouse model of Parkinson's disease, suggesting its neuroprotective potential.
research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines
This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.
research Immunomodulatory Potential of a Bibenzyl-dihydrophenanthrene Derivative Isolated from Calanthe cardioglossa
In this study, researchers isolated new compounds from the plant *Calanthe cardioglossa* and found that five of these compounds, particularly calancardin B, significantly reduced TNF-α levels in immune cells relevant to multiple sclerosis, suggesting potential for immunomodulatory effects.
research Anti-BPH lignans from Urtica triangularis subsp. pinnatifida (Hand.-Mazz.) C.J.Chen
This study found that compound 4 from Urtica triangularis subsp. pinnatifida exhibited stronger anti-BPH activity against BPH-1 cells with an IC50 of 79.75 μM compared to finasteride's IC50 of 91.8 μM, while compounds 1, 2, and 5 showed moderate activity.