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    Glossary Brepocitinib

    medication that inhibits enzymes involved in inflammation

    Brepocitinib is a medication that inhibits certain enzymes known as Janus kinases (JAKs) and tyrosine kinase 2 (TYK2). These enzymes play a role in the inflammatory process, and by blocking them, Brepocitinib can help reduce inflammation and is being studied for the treatment of autoimmune conditions like alopecia areata, psoriasis, and other inflammatory diseases.

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    Research 30 of 140

    1. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    2. Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers 2021 · 36 citations
    3. Maintenance, withdrawal, and re-treatment with ritlecitinib and brepocitinib in patients with alopecia areata in a single-blind extension of a phase 2a randomized clinical trial Journal of the American Academy of Dermatology · 2021 · 20 citations
    4. A phase 2a trial of brepocitinib for cicatricial alopecia Journal of the American Academy of Dermatology · 2024 · 17 citations
    5. 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers Journal of Investigative Dermatology · 2024
    6. 802 Molecular effect of brepocitinib in hidradenitis suppurativa (HS) Journal of Investigative Dermatology · 2024
    7. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    8. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    9. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    10. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    11. Adverse events in patients treated with Jak‐inhibitors for alopecia areata: A systematic review 2023 · 2 citations
    12. Alopecia areata: from pathophysiology to therapeutic innovation Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    13. Alopecia Areata in Skin of Color Patients: New Considerations Sparked by the Approval of Baricitinib Cutis · 2023 · 1 citations
    14. Use of Jak Inhibitors in the Treatment of Alopecia Areata Serbian Journal of Dermatology and Venerology · 2026
    15. LB1034 Meta-analysis of scalp transcriptome defines alopecia areata subtypes and molecular response to four (4) treatments with jak inhibiting properties Journal of Investigative Dermatology · 2024
    16. Review of the 2024 American Academy of Dermatology (AAD) Annual Meeting 2024
    17. Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis Frontiers in pharmacology · 2024
    18. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    19. Ritlecitinib: First Approval Drugs · 2023 · 84 citations
    20. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    21. Dupilumab induces hair regrowth in pediatric alopecia areata: a real-world, single-center observational study Archives of Dermatological Research · 2024 · 20 citations
    22. Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis Acta dermato-venereologica · 2023 · 10 citations
    23. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    24. Efficacy and safety of different JAK inhibitors in the treatment of alopecia areata: a network meta-analysis Frontiers in immunology · 2023 · 7 citations
    25. Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development Clinical Pharmacokinetics · 2023 · 6 citations
    26. Moving Beyond Boundaries: Utilization of Longitudinal Exposure–Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm Clinical Pharmacokinetics · 2024 · 5 citations
    27. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    28. Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis Frontiers in Pharmacology · 2025 · 3 citations
    29. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    30. Korean Consensus Criteria for the Severity Classification of Alopecia Areata Annals of Dermatology · 2024 · 3 citations