September 2007 in “MacSphere (McMaster University)” This study describes the molecular profile of mammary epithelial stem cells and breast cancer stem cells in vitro, which may aid in designing new breast cancer therapies by identifying potential biomarkers and therapeutic targets.
The authors concluded that capecitabine and high-dose toremifene may be an effective treatment option for patients unable to undergo anthracycline or taxane therapies, based on one woman's cancer management.
June 2003 in “Obstetrical & Gynecological Survey” Examining more lymph nodes can improve survival rates in breast cancer patients without lymph node involvement.
1461 citations
,
March 2004 in “Annals of oncology” This study found that in first-line treatment of metastatic breast cancer, pegylated liposomal doxorubicin (PLD) provided similar progression-free survival to doxorubicin with significantly less cardiotoxicity.
515 citations
,
April 2003 in “Endocrine Reviews” This review discusses hormone replacement therapy for menopausal women, emphasizing DHEA's unique ability to convert into sex steroids only in targeted tissues, and reports no new clinical results.
431 citations
,
October 2008 in “Current Medicinal Chemistry” This review focuses on coumarin analogs with potential antibreast cancer activities but reports no new clinical results, highlighting their mechanisms of action and structure-activity relationships.
388 citations
,
September 2000 in “Cancer” This study observed that the toxicity of Doxil in metastatic breast carcinoma patients is both dose and schedule dependent, with clear correlations to pharmacokinetic parameters.
61 citations
,
April 2009 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that irreversible and severe alopecia can occur following docetaxel or paclitaxel chemotherapy in breast cancer patients.
60 citations
,
August 2022 in “ESMO Open” This review discusses managing common and notable adverse events associated with the antibody-drug conjugate trastuzumab deruxtecan in patients with HER2-positive unresectable/metastatic breast cancer and reports no new clinical results.
59 citations
,
December 2016 in “Supportive Care in Cancer” This study found that symptom clusters in patients undergoing chemotherapy for breast cancer are stable over time, suggesting that targeting core symptoms may help reduce symptom burden.
56 citations
,
July 2014 in “PloS one” This study found that selective androgen receptor modulators (SARMs) significantly inhibited tumor growth and metastasis-promoting factors in AR-positive triple-negative breast cancer models.
52 citations
,
December 2020 in “Frontiers in Oncology” This review suggests that Chinese herbal medicine may help reduce side effects of chemotherapy in breast cancer patients, but a lack of high-quality trials limits confidence in this finding.
45 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the potential of plant polyphenols to overcome multidrug resistance in various solid cancers and reports no new experimental results; further research is suggested.
28 citations
,
July 2017 in “Expert Review of Anticancer Therapy” This study found that CDK4/6 inhibitors in hormone-positive metastatic breast cancer were linked to increased risks of fatigue, alopecia, and stomatitis compared to placebo.
24 citations
,
April 2017 in “Oncology Reports” In this study, full-size KRT81 was expressed in both normal breast epithelial and breast cancer cells, and contributed to the migration and invasion abilities of breast cancer cells.
16 citations
,
October 2012 in “British Journal of Dermatology” Chemotherapy can cause significant hair thinning and changes in hair texture, while tamoxifen has a smaller effect.
14 citations
,
January 2020 in “International Journal of Biological Sciences” This study explored the use of multiphoton microscopy to monitor changes in tumors and surrounding tissues in breast cancer patients undergoing neoadjuvant chemotherapy, finding it may effectively detect treatment response at cellular levels without using exogenous contrast agents.
13 citations
,
June 2023 in “Frontiers in Pharmacology” This meta-analysis reports that trastuzumab deruxtecan is effective and has an acceptable safety profile for treating HER2-low or positive advanced breast cancer, although further research is recommended to support individualized treatment strategies.
13 citations
,
August 1980 in “Cancer” This study found that administering chemotherapy to premenopausal women with Stage II breast cancer significantly improved disease-free intervals and increased survival, while postmenopausal women receiving sufficient doses also saw prolonged disease-free periods.
12 citations
,
September 2024 in “Frontiers in Immunology” This study found that metabolism-related genes significantly impact the prognosis and metastasis in breast cancer, and the development of prediction models may guide personalized therapeutic strategies.
10 citations
,
April 2007 in “Aesthetic Plastic Surgery” This study demonstrated the feasibility of a new patient-controlled method for tissue expansion that achieved full expansion in about 3 weeks with minimal complications after mastectomy.
9 citations
,
April 2018 in “JAMA Dermatology” This abstract provided no research findings as it contains only website navigation and service information.
8 citations
,
January 2020 in “Evidence-based Complementary and Alternative Medicine” This study found that Cinobufacin combined with chemotherapy improved clinical outcomes in breast cancer patients and reduced certain side effects compared to chemotherapy alone.
8 citations
,
September 2015 in “Journal of the European Academy of Dermatology and Venereology” This study observed that hair and scalp sensations were significantly more common and intense in chemotherapy patients compared to those receiving tamoxifen, with sensations ceasing after 11 weeks.
8 citations
,
June 2001 in “Journal of Biological Chemistry” This study found that the truncated hHb1-DeltaN transcript in breast cancer cells is produced by a cryptic intron promoter and responds to DNA demethylation, potentially altering cancer cell adhesion.
7 citations
,
February 2023 in “Plastic & Reconstructive Surgery” This study found that racial minorities face higher costs for unplanned hospital visits after surgery despite controlling for insurance, highlighting health care disparities and suggesting revised payment models as a potential mitigation strategy.
7 citations
,
May 2016 in “SpringerPlus” This review suggests that treating endocrine therapy-induced hair loss in breast cancer patients with topical 5-alpha reductase inhibitors and supplements like Vitamin C and omega-3 fatty acids may be effective, but further studies are needed.
6 citations
,
November 2021 in “Oncology Research and Treatment” This study found that lower expression of VDR protein in breast cancer patients is associated with increased bone metastasis and poorer prognosis, making it a significant prognostic factor.
5 citations
,
September 2024 in “Journal of Clinical Medicine” This article reviews the pathophysiology of chemotherapy-induced alopecia and reports that scalp cooling can reduce hair loss by 50% in patients with early breast cancer receiving chemotherapy, without compromising survival or increasing scalp metastasis risk.
5 citations
,
August 2024 in “Clinical & Translational Oncology” This review provides a comprehensive overview of multidisciplinary dermo-aesthetic interventions for breast cancer patients, aiming to establish safe protocols involving various specialists to improve quality of life, although consultation with an oncologist before treatment is advised.