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Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Tempol is safe and may prevent hair loss from brain radiotherapy.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Taking selenium supplements during chemotherapy may help reduce side effects and improve health markers in ovarian cancer patients.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Higher doses of cranial irradiation are linked to permanent hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Understanding the mouse hair cycle is crucial for cancer research.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Activating TRPV3 stops human hair growth.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.