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Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Some medicinal plants can help heal wounds and may lead to new treatments.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Higher doses of cranial irradiation are linked to permanent hair loss.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.

Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.

WNT10A helps esophageal cancer cells spread and keep renewing themselves.