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BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Researchers found WNT10A to be a key gene in developing goat hair follicles.

The WIF1 gene is crucial for hair growth in Angora rabbits.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Over 150 new molecules with biological activities were found in traditional herbal medicines, some with potential for new drug development.

Mouse Scube3 affects teeth, tongue, vibrissae, and eye development, but not facial structure or limb growth.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Microneedles are a promising method for drug delivery, offering efficient and convenient alternatives with fewer side effects.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

Estrogen-progestin contraception lowers ovarian, endometrial, and colon cancer risk but may raise breast and cervical cancer risk, helps with menstrual and acne issues, and new methods are as effective as pills. Metformin helps overweight women with PCOS and insulin resistance, and dopamine agonists treat prolactinomas.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Hirsutism is common body hair growth due to genetics and hormones, and while not a disease, it can be distressing; virilisation includes hirsutism with other male traits and needs medical attention.

Early diagnosis and treatment of Hidradenitis Suppurativa are important to prevent serious physical and mental effects.

Combining Traditional Chinese Medicine and Western medicine can improve symptoms, hormone levels, and pregnancy outcomes in Polycystic Ovary Syndrome patients, but more research is needed.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Evaluate postmenopausal women with high androgen levels using medical history, physical exams, lab tests, and imaging to manage health risks.

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.