11 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This study reviewed the prospects and challenges of using stem cells from adipose tissue in regenerative medicine for facial rejuvenation, emphasizing the need for further research to ensure patient safety before these methods can become routine in cosmetic and reconstructive surgery.
159 citations
,
November 2007 in “American Journal of Pathology” In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.
6 citations
,
August 2019 in “PLOS ONE” The researchers reported that Gambogic Amide may prevent hair greying and promote hair growth by maintaining follicle pigmentation in vitro through activation and migration of melanocytes.
January 2024 in “Theranostics” This study found that HDAC6 plays a crucial role in regulating primordial follicle activation, with its overexpression delaying activation and preserving fertility by reducing NGF levels.
34 citations
,
August 2005 in “Dermatologic Clinics” This review discusses how the brain can influence skin biology, suggesting a link between psychological factors and skin health, but it reports no new scientific findings.
This abstract introduces 3D bioprinted skin grafts as a promising alternative to traditional skin grafts, emphasizing how using stem cells in the bioink can enhance vascularization and hair follicle regeneration, potentially improving graft integration and function without the donor site risks.
39 citations
,
April 2019 in “Journal of Biomaterials Science, Polymer Edition” This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.
13 citations
,
February 2024 in “Clinical Epigenetics” In this study, the authors review how epigenetic regulation influences the role of iPSC-derived neural stem/progenitor cells in spinal cord injury therapy, highlighting challenges in the cells' generation, differentiation, and transplantation, and the effect of therapeutic tools on these processes.
36 citations
,
September 2009 in “Molecular Neurobiology”
220 citations
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March 2020 in “Advanced functional materials” This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.
87 citations
,
June 2010 in “Stem Cell Research & Therapy” This study demonstrated that epidermal neural crest stem cells and bone marrow-derived stem cells migrated toward inflammatory brain lesions in rats and were successfully tracked using noninvasive MRI.
This literature review on neurocosmetics found that both nature-derived peptides and synthetic molecules can improve skin concerns like aging and pigmentation, while also promoting emotional well-being; however, gaps in long-term efficacy and personalized approaches remain.
12 citations
,
February 2023 in “Stem Cell Research & Therapy” This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
11 citations
,
February 2019 in “Stem cells international” In this study, researchers found that while both hair follicles and skin dermis-derived neural crest stem cells are suitable for large-scale manufacturing, skin dermis cells grow faster and are easier to obtain.
May 2025 in “International Journal of Molecular Sciences” This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.
June 2024 in “Regenerative Therapy” This review highlights the potential of exosomes as a novel therapeutic approach for skin diseases and aging, due to their stability, transportability, and ability to carry various bioactive compounds to target cells.
November 2022 in “Regenerative Therapy” This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.
2 citations
,
January 2023 in “BioMed Research International” This review discusses the potential of mesenchymal stromal cell secretome therapies for facial nerve palsy, emphasizing their standardization advantages over cell transplantation, but provides no new clinical results.
7 citations
,
July 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that human skin can be efficiently reinnervated using human induced pluripotent stem cell-derived neural stem cells, promoting skin vitality and sensory reinnervation comparable to physiological conditions.
156 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
2 citations
,
January 2015 in “BioMed Research International” This article reviews various aspects of growth factor research, highlighting their role in treatments and emphasizing the need for further clinical trials to validate their efficacy in biomedical applications.
8 citations
,
December 2020 in “The FASEB Journal” Blocking adenosine A2B receptor may prevent or treat hearing loss.
The study found that conditioned medium from placental cells and sub-cultured placental tissue promoted angiogenesis in HUVECs, with early pregnancy cells showing more significant effects than those from full-term pregnancy.
3 citations
,
January 2020 in “PubMed” This study found that using insulin-like growth factor 1 with bone marrow-derived mesenchymal stem cells in a collagen-chitosan scaffold enhanced wound healing and hair follicle regeneration in rats.
44 citations
,
January 2015 in “Development” This study reports that human epidermal neural crest stem cells from hair follicles can be quickly differentiated into highly pure human Schwann cells without genetic manipulation, suggesting their potential for therapeutic applications.
57 citations
,
April 2009 in “Differentiation” This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.
7 citations
,
April 2019 in “Aesthetic Surgery Journal” This study found that repeated applications of both nonactivated and activated PRP in rats led to increased hypersensitivity to pain, which may be linked to elevated nerve growth factor levels and inflammatory mediators.
This review highlights various plant-based and herbal treatments that reportedly help prevent hair loss and encourage hair growth. It also explores the molecular mechanisms, identified plant compounds, recent technologies such as nanoarchitectonics, and patents related to hair growth promotion.
3 citations
,
June 2017 in “Journal of Biomaterials Applications” This study demonstrated that keratin extract can stimulate hair growth by inducing the anagen phase in telogenic mice.
2 citations
,
June 2016 in “International journal of experimental pathology” This study found that expression of GDNF and GFR α-1 proteins in human skin decreases with age, particularly in the epidermis, suggesting that their signaling pathways may be altered as people grow older.