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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Some drugs can cause hair loss, change hair color and shape, or increase hair growth, and treatment may involve stopping the drug or using specific hair growth treatments.

New treatments for male hypogonadism are effective and should be personalized.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.

Certain drugs that block specific enzymes can help treat prostate diseases.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.

Bismuth subgallate and borneol together improve skin wound healing better than when used separately or compared to other treatments.

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Certain skin conditions may indicate or increase the risk of Parkinson's disease.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

Baby's toe injury linked to mom's hair loss; check baby's toes and be careful with fruit gel snacks.