research Knockout of mTOR/Akt Inhibitor REDD1 Results in Hair Cycle-Independent Dermal Adipose Expansion by Promoting Adipocyte Differentiation
Removing REDD1 in mice increases skin fat by making fat cells larger and more numerous.
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research The stag as an historical source of materia medica
The document examines the historical use of the male red deer (Cervus elephas) in traditional medicine, highlighting its significance from classical times through the early modern period. Various parts of the stag, such as antlers, heart bone, and genitals, were believed to possess medicinal properties due to the animal's legendary vitality. These components were used to treat numerous health issues, including infections, infertility, sexual impotence, and baldness. The stag's body parts were incorporated into amulets, Galenic simples, and alchemical derivatives, reflecting a blend of folklore and early medical practices. Although the use of stag-derived medicines declined around 1750, some practices continue in Traditional Chinese Medicine today.
research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning
Changing how mesenchymal stromal cells are grown can improve their healing abilities.
research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome
The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
research The Rotterdam Study: 2014 Objectives and Design Update
The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.
research A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis
Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.
research Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline
The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.
research Quantitative Single-Cell Approaches to Stem Cell Research
New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.
research Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine
Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.
research Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives
Layer-by-Layer self-assembly is promising for biomedical uses like tissue engineering and cell therapy, but challenges remain in material safety and process optimization.
research Current Evaluation of Amenorrhea
Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
research Acne as a Chronic Systemic Disease
Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.
research Recommendations for Treatment of Nonclassic Congenital Adrenal Hyperplasia: An Update
The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.
research Nonclassic Adrenal Hyperplasia: Clinical Features, Diagnosis, and Treatment
Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.
research Skin Signs in Anorexia Nervosa
Anorexia nervosa can cause skin problems, which may help with early diagnosis and usually improve with treatment.
research Baldness, Acne, and Testicular Germ Cell Tumors
Men with testicular cancer were less likely to experience baldness and severe acne.
research The Therapeutic Potential of CRTH2/DP2 Beyond Allergy and Asthma
CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.
research Is Polycystic Ovary Syndrome a Sexual Conflict? A Review
The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.
research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways
Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.
research Effects of Anticonvulsant Drugs on Chromosomes
Anticonvulsant drugs may cause temporary chromosomal abnormalities.
research Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea
The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.
research Hirsutism, Postpartum Telogen Effluvium, and Male Pattern Alopecia
Hormonal changes during and after pregnancy can cause hair growth changes and hair loss, with treatments available for some conditions.
research Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications
Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.
research Techniques for Rejuvenation of the Neck Platysma
Direct excision techniques can rejuvenate the neck but may not enhance the jawline and could cause neck-face disharmony if done incorrectly.
research DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice
Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells
Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.
research A Case of Familial Male-Limited Precocious Puberty with a Novel Mutation
A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.
research Cushing's Syndrome in the Elderly: Data From the European Registry on Cushing's Syndrome
Older patients with Cushing's syndrome often have different symptoms and treatment outcomes compared to younger patients.
research A Population-Based Study of the Risk of Osteoporosis and Fracture with Dutasteride and Finasteride
Dutasteride and finasteride have similar risk for osteoporosis and fractures in older men.