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The reviewers suggest major revisions for clarity and inclusion of recent findings on inflammation's role in cancer.

Reviewers suggest clarifying the abstract, adding background on inflammation's effect on cancer, discussing immune cell roles, including counter studies, and correcting grammar.

New materials that better mimic natural skin structure could improve healing, especially for chronic wounds.

The reviewers suggest clarifying and expanding on the role of inflammation in stem cell-related cancer development.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Creating fully functional artificial skin for chronic wounds is still very challenging.

Cytokines are important for immune responses and treating diseases, but they can cause side effects like fever and skin issues.

Dermal macrophages might help regrow hair.

Stem cell niches support, regulate, and coordinate stem cell functions.

The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

Ozone therapy might improve cancer treatment and reduce its side effects.

Cavity macrophages gather on organ surfaces but don't really invade or help repair the organs after injury.

Bioengineered salivary glands in mice can produce saliva when tasting sour or bitter, but have different protein levels and nerve signals compared to natural glands.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Nude mice with grafted human skin developed scars similar to human hypertrophic scars.

Disrupting Notch signaling in blood vessels increases scarring during wound healing in mice.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

The spiny mouse can regenerate its skin without scarring, which could help us learn how to heal human skin better.

Skin problems are common in lupus, often appearing first, with various types and treatments, and careful monitoring is important for diagnosis and management.

Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.

Nanomaterials show promise in improving wound healing but require more research on their potential toxicity.

MicroRNAs are crucial for skin development, regeneration, and disease treatment.

Innovative biomaterials show promise in healing chronic diabetic foot ulcers.

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.