50 citations,
January 2016 in “The FEBS journal” RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
10 citations,
August 2021 in “EMBO Reports” The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.
[object Object] 10 citations,
June 2021 in “EMBO reports” When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.
2 citations,
October 2022 in “Journal of Biomedical Science” Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Immune cells are essential for early hair and skin development and healing.
321 citations,
January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
11 citations,
March 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of skin stem cells was found to help maintain hair follicle cells.
52 citations,
February 2012 in “PloS one” Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
7 citations,
January 2020 in “Nature” Stress turns hair white by depleting color-giving cells in hair follicles through a specific neurotransmitter related to the body's stress response.
3 citations,
December 2023 in “Cell proliferation” Stuff from umbilical cord stem cells helps skin heal and look younger.
June 2024 in “Research Square (Research Square)” Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.
211 citations,
May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
89 citations,
January 2009 in “Advances in Clinical Chemistry” Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.
29 citations,
May 2020 in “npj Regenerative Medicine” Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
6 citations,
December 2011 in “Nature” The circadian clock in skin cells controls their growth and rest cycles.
1 citations,
August 2023 in “Nature communications” Hdac1 and Hdac2 help maintain and protect the cells that control hair growth.
The revised study on how inflammation affects cancer stem cells was accepted after improving clarity and structure.
The revised manuscript on how inflammation affects cancer stem cells was accepted after addressing issues with clarity and detail.
The reviewers found the manuscript on inflammation's role in cancer stem cells to be relevant but suggested it needs clarity, more background information, discussion on immune cells' role in tumors, updated references, and grammar corrections.
6 citations,
April 2010 in “Cellular Reprogramming” Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.
The reviewers suggest clarifying the abstract, adding background on inflammation's effect on stem cells and cancer, discussing immune cells' role in tumors, and considering inflammation's potential to reduce cancer growth.
218 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
1 citations,
October 2022 in “Annual review of cell and developmental biology” The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
65 citations,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
1 citations,
September 2022 in “Oxidative Medicine and Cellular Longevity” Hair follicle stem cells can help treat ulcerative colitis in mice by releasing beneficial exosomes.
June 2022 in “Pflügers Archiv - European Journal of Physiology” The enzyme sEH is important for hair growth and its inhibition could help treat hair loss.
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
3 citations,
February 1976 in “Pediatric Clinics of North America” The conclusion is that effective cancer treatment often requires a combination of therapies, but must be carefully managed due to serious side effects and the risk of immunosuppression.
May 2023 in “Frontiers in Cell and Developmental Biology” The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.
[object Object] PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.