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Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Doctors need to be better prepared to assess and treat obesity in patients.

Researchers found 15 new genetic links to skin traits in Japanese women.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.

Metabolic syndrome linked to female hair loss; waist size and high blood pressure important factors.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

Certain drugs change freshwater snail shells to a "banana" shape.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

Short daily photoperiods improve cashmere production in Inner Mongolia white cashmere goats.

Resveratrol helps prevent finasteride-induced damage in male rats, improving reproductive function.