64 citations
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March 2017 in “Nature communications” This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.
64 citations
,
July 2016 in “Cold Spring Harbor Perspectives in Medicine” The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
63 citations
,
December 1988 in “International Journal of Dermatology” Vitiligo causes white skin patches and is linked to autoimmune issues.
62 citations
,
February 2011 in “Expert review of dermatology” This review discusses the incidence, reversibility, and impact of chemotherapy-induced alopecia and concludes that scalp cooling is the most effective prevention method in most cases, though some questions remain.
62 citations
,
April 2008 in “Neurobiology of aging” This study identified a new genetic locus, ahl4, on distal Chromosome 10 that contributes to the early-onset, severe hearing loss in A/J mice compared to B6 mice.
60 citations
,
July 2011 in “Stem Cells and Development” This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.
60 citations
,
August 2008 in “Human molecular genetics online/Human molecular genetics” This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.
60 citations
,
June 1997 in “Journal of The American Academy of Dermatology” This review discusses the basic biology of apoptosis and its relevance to skin diseases, without presenting new research findings.
58 citations
,
December 2020 in “Mayo Clinic Proceedings” This paper discusses the variability in COVID-19 susceptibility and severity, emphasizing factors like biological differences and suggesting potential precision medicine approaches, but it reports no new clinical results.
58 citations
,
March 2013 in “Human Reproduction Update” This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.
58 citations
,
April 2012 in “Journal of the American Academy of Dermatology” Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.
58 citations
,
April 2009 in “Dermatologic Surgery” This study presents guidelines for designing female hairlines, noting that most women in the sample had a widow's peak and specific average measurements for hairline features.
58 citations
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June 1987 in “Archives of Dermatological Research” This study found that epidermal and fibroblast growth factors increased proliferation of human hair bulb papilla cells and root sheath fibroblasts in vitro, while hydrocortisone decreased it and minoxidil had no effect.
57 citations
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November 1987 in “Pediatric Dermatology” This article reviews common hair growth abnormalities in children, emphasizing the importance of distinguishing normal development from potential signs of metabolic disorders and indicates no new clinical results.
57 citations
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June 2021 in “Polymers” This review discusses photothermal agent hybrids in hydrogels for antibacterial action, angiogenesis, and osteogenesis in tissue engineering, but reports no new experimental findings.
57 citations
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September 2017 in “Journal of controlled release” This review discusses recent advances in using nanocarrier-loaded gels for various medical applications and reports no new clinical results, highlighting potential advantages in therapeutic strategies.
57 citations
,
November 2006 in “International Journal of Cancer” This study found that the SRD5A2 A49T A variant is associated with an increased risk of prostate cancer, lower circulating 3α‐diolG levels, and a decreased risk of baldness.
56 citations
,
January 2015 in “Circulation” This study found that finasteride treatment improved cardiac function and reduced heart failure progression in mice, suggesting it could be a potential therapy for pathological cardiac hypertrophy and dysfunction.
55 citations
,
October 2019 in “Dermatology and therapy” This review found that JAK/STAT pathway inhibitors, such as tofacitinib and ruxolitinib, led to symptom improvement in all observed atopic dermatitis cases, but responses were mixed for vitiligo and alopecia areata, with a generally mild safety profile reported.
55 citations
,
August 2015 in “AAPS PharmSciTech” This study reports that a newly developed polyherbal phospholipid complex cream containing Citrus auranticum and Glycyrrhiza glabra extracts improved polyphenol retention in the skin, suggesting potential as an anti-aging cosmeceutical.
53 citations
,
June 2012 in “Annales d'Endocrinologie” This review discusses the range and causes of adipose tissue diseases, emphasizing genetic and acquired forms of lipodystrophy, but it reports no new clinical results.
53 citations
,
May 1987 in “The Lancet” The document suggests a possible link between Crohn's disease and Johne's disease and calls for more research.
52 citations
,
October 2010 in “Antiviral Therapy” This review discusses recent advances in monophosphate prodrug strategies for HCV drug discovery, aiming to enhance oral absorption and stability, and reports no new clinical results.
51 citations
,
June 2021 in “Signal Transduction and Targeted Therapy” This review article summarizes recent strategies to enhance the precise control of CRISPR/Cas9 gene editing, addressing tissue-specific challenges and off-target effects by exploring various activation methods like cell-specific promoters and small molecules.
51 citations
,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
50 citations
,
March 2021 in “Journal of investigational allergology & clinical immunology” This review examines existing research and clinical trials on the use of dupilumab for various skin, respiratory, and gastrointestinal disorders, but it reports no new clinical findings.
50 citations
,
November 2010 in “Otolaryngologic Clinics of North America” This review discusses the oral manifestations associated with hematologic conditions and nutritional deficiencies, without presenting new research results; it emphasizes the impact of blood disorders and vitamin deficiencies on oral health.
50 citations
,
May 2019 in “Drugs” This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.
48 citations
,
February 2016 in “Scientific Reports” This study reports the creation of rat liver stem cell lines that can differentiate into hepatocytes and suggests they might be useful for pharmacological and regenerative medicine applications.
48 citations
,
July 2002 in “Journal of Cutaneous Medicine and Surgery” This review discusses the variety of skin conditions linked to eating disorders and emphasizes that resolving these skin issues often requires treating the underlying disorder.