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In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.

In this study, researchers found that hydrogel scaffolds loaded with Runx2-overexpressing BMSCs significantly enhanced bone regeneration and osteogenic differentiation, offering new insights into treating large bone defects.

This study demonstrated that epidermal neural crest stem cells and bone marrow-derived stem cells migrated toward inflammatory brain lesions in rats and were successfully tracked using noninvasive MRI.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

This review explores the potential of using genetically-manipulated stem cells as both therapeutic agents and gene delivery vehicles for enhanced wound regeneration, but it reports no new clinical results.

This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.

This study found that combining Panax notoginseng saponins with bone mesenchymal stem cells significantly enhanced diabetic cutaneous ulcer healing in rats by reducing inflammation and promoting new epidermis formation through specific molecular pathways.

This study found that injecting bone marrow-derived mesenchymal stem cells and conditioned medium into mice promoted hair follicle stem cell proliferation and transition to active growth phases, suggesting potential clinical targets for hair loss treatment.

This study observed that bone marrow mesenchymal stem cells cultured in three-dimensionally bioprinted hydrogels with higher stiffness, like 3A8G, tend to differentiate more into hair follicle cells compared to those in less stiff hydrogels, like 1A4G.

This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.

This study describes the use of a genetically engineered mouse model, mTurquoise2-Col4a1, to fluorescently label collagen IV and observe basement membrane dynamics during skin development, revealing its stability and pliability during rapid growth phases.

This study observes that TYK2 inhibition with BMS-986202 may extend hair follicle growth phases and decrease inflammatory cell markers in alopecia areata, suggesting potential for clinical application.

ITK inhibitors may effectively treat alopecia areata.

In this study, researchers found that ex vivo and in vivo administration of the TYK2 inhibitor BMS-986202 prevented immune privilege collapse and promoted hair regrowth in models of alopecia areata, suggesting this approach may offer a new therapeutic avenue deserving of clinical investigation.

This study found that a TYK2 inhibitor, BMS-986202, may restore immune privilege in hair follicles and promote hair regrowth in a humanized alopecia areata mouse model by inhibiting IL-12-mediated signaling.

This study found that interleukin-12 signals play a role in hair follicle immune privilege collapse in ex vivo alopecia areata models, and a TYK2 inhibitor may help prevent or reverse this process.

This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.

This study used a novel fluorescent tagging method in mice to observe collagen IV dynamics during hair follicle development, revealing that alterations in basement membrane turnover can influence epithelial progenitor cell behavior and organ morphology by affecting cell proliferation and movement.

This study found that direct co-culture of human bone marrow-derived mesenchymal stromal cells with regulatory T cells enhanced osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization, suggesting Treg's potential in promoting bone regeneration by modulating BMSC mechanobiology through the ROCK-myosin signaling pathway.

This study found that far-infrared radiation preconditioning significantly enhanced the proliferation, survival, and migration of bone marrow-derived stem cells in vitro, indicating potential therapeutic benefits for cardiac ischemia treatment.

In this rat study, bone marrow mesenchymal stem cell therapy reduced mortality and intestinal damage in acute liver failure by alleviating endotoxemia.

This study found that human dermal papilla cells are surrounded by a basement membrane-like extracellular matrix, which maintains their aggregated structure without strong cell‒cell contacts.

This study found that hydrogels loaded with exosomes from bone marrow mesenchymal stem cells helped bone fracture healing by reducing inflammation, promoting blood vessel formation, and supporting bone regeneration, as confirmed in a mouse model.

This study reported that high-intensity red LED irradiation increased osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells, potentially through Wnt/β-catenin pathway activation.

This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.

In this study, shear-thinning silk nanofiber hydrogels were found to enhance retention of mesenchymal stem cells and accelerate wound healing in rat models.

Mercury allergy linked to specific genes may contribute to burning mouth syndrome, and silicon might play a role in maintaining healthy hair.