18 citations
,
December 2010 in “The Journal of Steroid Biochemistry and Molecular Biology” The authors concluded that increased expression of the HSD11B1 gene in adipose tissue correlates with obesity markers and predicts insulin resistance, but this association is independent of polycystic ovary syndrome when adiposity is controlled for.
18 citations
,
July 2010 in “Expert Review of Endocrinology & Metabolism” This study identified an association between the FTO gene and susceptibility to PCOS, providing the first genetic evidence linking PCOS to obesity.
17 citations
,
May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews” This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.
17 citations
,
January 2016 in “Advances in Dermatology and Allergology” In this study, isotretinoin treatment for acne vulgaris significantly increased serum adiponectin and leptin levels but had no significant effect on BMI or ghrelin levels.
17 citations
,
July 2015 in “Biomolecules and Biomedicine” This study found that women with PCOS had higher levels of Nesfatin-1 and lower levels of vitamin D, which may be linked to increased blood pressure and potential hypertension.
17 citations
,
January 2014 in “Journal of Clinical and Diagnostic Research” This study found that patients with oral lichen planus and oral lichenoid reactions have higher levels of serum cholesterol and LDL-C than healthy individuals, suggesting a potential elevated risk for cardiovascular disease.
17 citations
,
December 2011 in “Journal of the European Academy of Dermatology and Venereology” People with vitiligo may have a lower risk of heart disease.
16 citations
,
November 2021 in “Antioxidants” This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.
16 citations
,
October 2020 in “Lipids in Health and Disease” This review explores the current understanding of leptin's role in psoriasis and other skin diseases but reports no new clinical findings, emphasizing that the exact mechanisms of its impact are still being investigated.
16 citations
,
March 2015 in “Wiener Klinische Wochenschrift” Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.
16 citations
,
April 2007 in “Journal of Obstetrics and Gynaecology Research” In this study, serum PSA levels were higher in women with PCOS, suggesting it may serve as a marker for hyperandrogenism in this condition.
16 citations
,
June 2005 in “Clinical and Experimental Dermatology” In this study of 30 severe anorexia nervosa patients, true acquired pili torti was not found although twisted hair was observed in 6.6% of cases.
15 citations
,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” In this study of women with polycystic ovary syndrome, insulin resistance was associated with obesity, waist circumference, lipid accumulation, and hypertension, with no significant difference in prevalence between different diagnostic methods.
15 citations
,
August 2017 in “Scientific Reports” This study found that young men with early-onset androgenetic alopecia have a worse glycolipid profile and hormone pattern similar to women's PCOS, suggesting a possible male PCOS-equivalent syndrome.
15 citations
,
January 2010 in “Reproduction, Fertility and Development” This study found that Han Chinese women carrying the rs6152A allele had a significantly higher risk of developing polycystic ovary syndrome compared to those with the rs6152GG genotype.
14 citations
,
December 2019 in “Iraqi Journal of Science” In this study, women with polycystic ovary syndrome had higher body mass index and hormone levels compared to healthy women, with hyperandrogenism symptoms like hirsutism and alopecia more prevalent among the obese participants.
14 citations
,
August 2019 in “BioMed Research International” This study found that abdominal obesity was the primary predictive factor for nonalcoholic fatty liver disease in women, rather than the presence of polycystic ovary syndrome.
13 citations
,
February 2020 in “Clinical, Cosmetic and Investigational Dermatology” In this study, men with androgenetic alopecia had lower BMI and waist-to-hip ratios than controls, but no significant association with hypertension or other lifestyle factors was observed.
13 citations
,
October 2011 in “Clinical Obstetrics and Gynecology” This review covers the diagnosis of polycystic ovary syndrome and the management of related infertility, describing evaluation and initial treatment steps, without presenting new clinical results.
13 citations
,
May 1996 in “Archives of Disease in Childhood” This study found that patients with non-classical 21-hydroxylase deficiency do not appear to be at risk of short adult stature despite increased bone age in childhood.
12 citations
,
November 2019 in “PLoS ONE” This study suggests a weak association between male-pattern baldness and some coronary heart disease risk factors, but does not support it as a strong indicator of coronary risk.
12 citations
,
August 2019 in “BMC Medical Genetics” This study found that two MC4R gene polymorphisms are associated with higher BMI in women with PCOS in western Saudi Arabia, but are not linked to PCOS itself.
12 citations
,
May 2005 in “Fertility and Sterility” This study suggests that insulin levels may influence ovarian volume in women with idiopathic hirsutism who have normal ovulatory cycles and androgen levels.
11 citations
,
March 2021 in “Reproductive Biology and Endocrinology” This study found that bloating is the most frequently reported symptom and a main predictor of polycystic ovary syndrome among women using the Flo app across five countries.
11 citations
,
May 2020 in “Frontiers in psychiatry” This study found that experiencing childhood abuse is associated with higher BMI, but hair cortisol and cortisone do not mediate this relationship.
11 citations
,
April 2019 in “Bioscience Reports” In this study, single nucleotide polymorphisms in the RAB5B gene were linked to an increased risk of polycystic ovary syndrome and associated with specific microRNA binding sites.
11 citations
,
October 2018 in “Hormone and Metabolic Research” This study found no difference in bone mineral density between young women with PCOS and age- and BMI-matched controls, but BMI significantly influenced BMD in women with PCOS.
11 citations
,
November 2017 in “Electronic physician” In this study, no significant correlation was found between depression scores and body mass index, HOMA-IR, or testosterone levels in women with or without polycystic ovary syndrome.
11 citations
,
August 2014 in “PubMed” This study found that women with acne had higher rates of hyperandrogenism and obesity, and higher androgen levels and BMI were linked to increased acne severity.
10 citations
,
February 2017 in “Hormone Molecular Biology and Clinical Investigation” This randomized clinical trial found that vitamin D supplementation did not significantly alter anthropometric or metabolic parameters in obese, insulin-resistant, and vitamin D-deficient women with polycystic ovary syndrome, whereas metformin effectively reduced body weight, BMI, waist circumference, total body fat, and serum glucose levels.