September 2019 in “Journal of evolution of medical and dental sciences” In this study of patients with obesity, the most common skin disorders observed were acanthosis nigricans, skin tags, and stretch marks, emphasizing the impact of obesity on dermatological health.
45 citations
,
September 2011 in “Journal of the European Academy of Dermatology and Venereology” This study found that obesity is associated with several skin conditions, such as striae and pseudoacanthosis nigricans, which may serve as markers of excessive weight.
30 citations
,
November 2021 in “Obesity Reviews” This meta-analysis found a consistent positive association between glucocorticoids in hair and obesity measures, with the relationship between hair cortisone and waist circumference being particularly clinically relevant.
16 citations
,
January 2012 in “Indian Journal of Endocrinology and Metabolism” This case series describes six women with both PCOS and Graves' disease, suggesting a possible shared underlying cause for their co-occurrence.
13 citations
,
March 2019 in “Physiological Research” This study found that among women with polycystic ovary syndrome, higher levels of the hormones estrone and free testosterone were associated with an increased cardiometabolic risk, especially in those who were overweight or obese.
6 citations
,
August 2013 in “Fertility and Sterility” This study found that cream ingestion increased NFκB activation in women with PCOS, which was associated with insulin resistance and higher ovarian androgen levels, regardless of obesity status.
February 2020 in “Research Square (Research Square)” In this study, skin tags in Irish adults with morbid obesity were associated with higher blood pressure, higher HbA1c levels, and a greater prevalence of diabetes and hypertension, suggesting increased cardiovascular risk.
128 citations
,
January 2023 in “Frontiers in Endocrinology” This review discusses recurrent implantation failure (RIF) in IVF, noting the lack of standard definitions or treatment protocols, and emphasizes the need for individualized treatment and further research.
128 citations
,
September 2011 in “British Journal of Dermatology” Obesity is linked to various skin problems and may increase the risk of skin cancer.
90 citations
,
February 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with polycystic ovary syndrome have higher global adiposity and increased visceral fat, particularly in the ip and mesenteric depots, compared to women without androgen excess.
68 citations
,
April 2002 in “Journal of Human Nutrition and Dietetics” This study found that although diabetic patients undergoing a very low calorie diet experienced faster weight loss initially, those on a conventional diet and exercise plan maintained weight loss more effectively over five years.
62 citations
,
April 2013 in “Steroids” This review discusses the age-related diagnostic challenges and comorbidities of polycystic ovarian syndrome and provides no new clinical findings; the authors emphasize the role of obesity in insulin resistance among affected women.
50 citations
,
June 2014 in “Experimental and Clinical Endocrinology & Diabetes” This study found that hair cortisol levels increase and testosterone levels decrease with obesity, suggesting that measuring hormones in hair may be a valuable tool in obesity research and clinical practice.
32 citations
,
October 2023 in “Biomedicines” This study found that chronic low-grade inflammation exists independently of excess weight or obesity in women with PCOS, with notable increases in specific cytokines such as IL-9, MCP-3, and MIP-1α.
29 citations
,
September 2023 in “Journal of Clinical Medicine” This study found that semaglutide significantly reduced body weight in almost 80% of obese PCOS patients unresponsive to lifestyle changes, often normalizing menstrual cycles with few side effects.
26 citations
,
August 2014 in “Genetic Testing and Molecular Biomarkers” This study suggests that the TNF-α system may contribute to hyperandrogenism, obesity, and insulin resistance in polycystic ovarian syndrome, independent of the C850T polymorphism.
21 citations
,
July 2016 in “Gynecological Endocrinology” This study found that women with polycystic ovary syndrome have elevated cardiovascular risk markers, with levels being higher in obese participants compared to non-obese participants.
21 citations
,
December 2012 in “Biological Trace Element Research” Higher hair levels of calcium and magnesium are linked to higher body weight, while lower levels are linked to worse metabolic health.
21 citations
,
October 2011 in “British Journal of Dermatology” This study found that subcutaneous testosterone therapy improved scalp hair growth in a majority of androgen-deficient women who previously reported hair thinning and did not report hair loss as a side effect.
18 citations
,
September 2017 in “Clinics in Dermatology” This review highlights the role of dermatologists in detecting early cutaneous signs of obesity-related metabolic syndrome, which may enable earlier treatment to prevent long-term consequences; it reports no new clinical results.
17 citations
,
September 2017 in “Journal of Cosmetic Dermatology” In this study of women with PCOS, hirsutism strongly correlated with metabolic abnormalities, while acne and androgenic alopecia were not clear markers of biochemical hyperandrogenemia or metabolic dysfunction.
17 citations
,
May 2012 in “Clinical Endocrinology” This study found that surgical normalization of testosterone in hyperandrogenic women with ovarian androgen-secreting tumors did not significantly change body weight or insulin sensitivity after 12 months.
14 citations
,
January 2015 in “ABCD” This study found that Roux-en-Y gastric bypass was effective in significant weight loss and improved lipid profiles in obese women during the first postoperative year, though some experienced alopecia, asthenia, dry skin, and cramps.
14 citations
,
August 2014 in “Applied Physiology, Nutrition, and Metabolism” This study concluded that an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS.
13 citations
,
April 2015 in “Human Reproduction” Obese Hispanic women with PCOS are at higher risk for metabolic problems than non-Hispanic white women.
8 citations
,
August 2016 in “Annales de Dermatologie et de Vénéréologie” This case report details a rare instance of scurvy linked to anorexia nervosa in a 48-year-old woman, characterized by atypical symptoms and successfully treated with vitamin C supplements.
7 citations
,
August 2017 in “Journal of Evolution of Medical and Dental Sciences” This study found that women with polycystic ovary syndrome had significantly higher levels of periodontal disease compared to women without the condition.
6 citations
,
February 2014 in “Actas Dermo-Sifiliográficas” This study found that acanthosis nigricans and skin tags in nondiabetic, obese patients were significantly associated with higher insulin levels, suggesting they may serve as clinical markers of hyperinsulinemia.
4 citations
,
January 2018 in “JBRA assisted reproduction” This study found that orlistat significantly reduced weight and total testosterone levels in Iranian women with polycystic ovary syndrome after 12 weeks of treatment.
2 citations
,
April 2023 in “Diabetes Metabolic Syndrome and Obesity” 2h-ICPR can help screen for insulin antibodies in type 2 diabetes patients.