48 citations
,
July 2019 in “International Journal of Biological Macromolecules” This study found that a newly developed injectable hydrogel combined with human umbilical cord-mesenchymal stem cells significantly accelerated wound healing and reduced inflammation in full-thickness cutaneous wounds.
45 citations
,
August 2018 in “Haematologica” This study found that iron retention in macrophages impairs hair follicle growth and delays wound healing in mice, highlighting the importance of macrophage iron release for skin health.
45 citations
,
July 2006 in “Journal of Investigative Dermatology” This study found that doxorubicin disrupts hair-follicle-associated blood vessels, which may contribute to hair follicle dystrophy and alopecia in mice, but hair-follicle stem cells remained unaffected.
19 citations
,
April 2021 in “Stem Cell Research & Therapy” This study found that transplantation of autologous stromal vascular fraction cells increased skin thickness and improved regeneration when combined with mechanical stretching, without severe adverse events.
16 citations
,
February 2013 in “Molecular Medicine Reports” This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.
December 2025 in “Molecules” This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.
May 2024 in “Journal of Advanced Research” In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.
This study found that dermal papilla-like tissues derived from canine adipose stem cells promoted new hair follicle formation and increased vascularization in athymic nude mice.
April 2021 in “Journal of Cosmetic Dermatology” Stem cell treatment improved hair density in female hair loss patient.
1 citations
,
May 2022 in “Frontiers in medicine” This study found that topical application of metformin significantly enhanced skin regeneration in mechanically stretched skin in rats, likely by boosting the proliferation of skin-derived stem cells.
1 citations
,
October 1988 in “Clinics in dermatology” This paper explores cell kinetics in human hair follicles, focusing on the proliferation rates of keratinocytes and dermal papilla cells, but provides no new experimental findings.
This study reports that follicular cells isolated from murine skin can regenerate hair follicles after being injected into nude mouse skin, with the regeneration process relying on cell interactions, recipient sites, and cell numbers.
January 2022 in “Stem cell biology and regenerative medicine” This review explores the complex interactions between hair follicle stem cells and surrounding structures that are essential for understanding hair regeneration, reporting no new experimental results.
132 citations
,
January 2017 in “International Journal of Molecular Sciences” This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.
8 citations
,
May 2019 in “Journal of Stem Cells & Regenerative Medicine” This study found that mesenchymal stem cells derived from dental pulp and adipose tissue have distinct gene expression signatures that suggest potential target diseases for clinical applications.
8 citations
,
January 2016 in “Journal of Veterinary Medical Science” This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.
2 citations
,
November 2023 in “Laboratory Animal Research” In this study, the combination of conditioned medium from human adipose-derived stem cells and photobiomodulation significantly enhanced wound healing in type 2 diabetic rats compared to using either treatment alone, with particularly superior results in wound strength and new blood vessel formation.
1 citations
,
October 2015 in “CRC Press eBooks” This article reviews the use of autologous platelet-rich plasma (PRP) in hair restoration, discussing its potential benefits for follicle health and regeneration, but it reports no new clinical findings.
2 citations
,
September 2022 in “Cytotherapy” This review summarizes recent research on the therapeutic uses of adipose-derived stem cells for wound healing and treating skin diseases but does not provide new experimental results.
October 2022 in “Academic journal of science and technology” This article introduces types of hair loss and treatments, explores stem cell applications, and describes adipose-derived stem cells' potential in hair regeneration, but reports no clinical results and highlights limitations.
76 citations
,
March 2005 in “Cancer Research” This study in ND-GFP transgenic mice found doxorubicin inhibited both tumor angiogenesis and growth, visualized through dual-color fluorescence imaging of nascent blood vessels and melanoma cell lines.
2 citations
,
August 2022 in “Frontiers in Endocrinology” This study reported that myeloid-specific Wnt production did not affect wound healing or blood vessel density in mice but influenced endovascular progenitor cell kinetics during angiogenesis.
3 citations
,
January 2023 in “Materials horizons” This study developed 3D micropatterns with magnesium silicate nanospheres that mimic vessels and hair follicles for potential use in skin regeneration by reconstructing vasculature and promoting hair growth.
This study suggests that topically applied thyroid hormones T3 and T4 promote hair growth on human scalp tissues ex vivo, highlighting potential therapeutic use for hair loss conditions like androgenetic alopecia.
November 2023 in “Journal of Investigative Dermatology” This research investigated immune cell involvement in various types of inflammatory alopecia by analyzing gene expression data from scalp samples, revealing distinct cellular changes in conditions like Alopecia Areata, Frontal Fibrosing Alopecia, Lichen Planopilaris, and Central Centrifugal Cicatricial Alopecia, which may inform future therapeutic targets.
37 citations
,
May 2021 in “Frontiers in Cell and Developmental Biology” This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.
359 citations
,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” This article reviews the role of skin appendages in wound healing and appendage regeneration, discussing cellular and molecular mechanisms but reports no new experimental findings.
162 citations
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July 2011 in “Biomacromolecules” This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.
13 citations
,
January 2015 in “Stem cells international” This article reviews the complex roles and therapeutic potential of Mesenchymal Stem Cells across various medical applications, emphasizing their anti-inflammatory and tissue repair functions rather than cell replacement or differentiation, and concludes that more precise measurement of their survival and effectiveness is needed.
April 2025 in “ALEXMED ePosters” This study reported that CXCL12 may have a dual role in alopecia areata, where decreased levels could impair angiogenesis and disrupt vascular support to hair follicles, while its overexpression might exacerbate autoimmune attacks on hair follicles, contributing to hair loss.